Anti-PF4/heparin antibodies are increased in hospitalized patients with bacterial sepsis.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.09.060
Abstract: Heparin-induced thrombocytopenia (HIT) is caused by antibodies targeting platelet factor 4 (PF4)/heparin complexes. The immune response leading to HIT remains perplexing with many paradoxes. Unlike other drug induced reactions, anti-PF4/heparin antibody generation does not follow… read more here.
Keywords: antibody; sepsis; pf4 heparin; anti pf4 ... See more keywords
Platelet-activating anti-PF4 disorders: An overview.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2022.02.005
Abstract: Platelet factor 4 (PF4) is a highly cationic tetrameric protein that can be targeted by platelet-activating anti-PF4 antibodies of immunoglobulin G (IgG) class. Certain features of PF4, including its multivalent nature (duplicate antigen sites per… read more here.
Keywords: platelet activating; pf4 disorders; pf4; activating anti ... See more keywords
Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology
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DOI: 10.1080/09537104.2022.2042238
Abstract: Abstract Thromboembolic events are frequent and associated with poor outcome in severe COVID-19 disease. Anti-PF4/polyanion antibodies are related to heparin-induced thrombocytopenia (HIT) and thrombus formation, but data on these antibodies in unselected COVID-19 populations are… read more here.
Keywords: covid patients; polyanion antibodies; pathology; anti pf4 ... See more keywords
High ANTI‐PF4/Heparin Antibodies Titer and Thromboses Due to Infection 9 Months After Cessation of Heparin in Hemodialyzed Patient With Heparin‐Induced Thrombocytopenia
Sign Up to like & getrecommendations! Published in 2018 at "Therapeutic Apheresis and Dialysis"
DOI: 10.1111/1744-9987.12699
Abstract: Superficialization of an AVF as second stage procedure by means of flap elevation (1) and open lipectomy (2), have been shown to be effective yet invasive options to prepare the cephalic vein for needling in… read more here.
Keywords: technique; heparin; vein; high anti ... See more keywords
Production of anti-PF4 antibodies in antiphospholipid antibody-positive patients is not affected by COVID-19 vaccination
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DOI: 10.1136/rmdopen-2021-001902
Abstract: Background Antibodies against cationic platelet chemokine, platelet factor 4 (PF4/CXCL4), have been described in heparin-induced thrombocytopenia (HIT), but also in patients positive for antiphospholipid antibodies (aPL) even in the absence of heparin treatment and HIT-related… read more here.
Keywords: vaccination; pf4 antibodies; platelet; positive patients ... See more keywords
The Relevance of Anti-PF4 Antibody Isotypes and Endogenous Glycosaminoglycans and their Relationship with Inflammatory Biomarkers in Pulmonary Embolism Patients
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DOI: 10.1177/10760296221091770
Abstract: Introduction Previous studies have shown that inflammation may contribute to the interplay of endogenous glycosaminoglycans (GAGs) and anti-PF4 antibodies. In this study, we quantified the levels of anti-PF4 antibody isotypes and endogenous GAGs together with… read more here.
Keywords: anti pf4; inflammatory biomarkers; pf4; antibody isotypes ... See more keywords
Cleavage of Anti-PF4/H IgG Antibodies By Ides, and Potential Benefit in the Treatment of Heparin-Induced Thrombocytopenia
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DOI: 10.1182/blood-2018-99-114450
Abstract: Heparin-induced thrombocytopenia (HIT) is a severe drug-adverse event due to platelet-activating antibodies (Abs) directed against platelet factor 4 (PF4)/heparin (H) complexes. In most patients, HIT Abs are IgG that directly activate platelets and monocytes in… read more here.
Keywords: heparin; pf4 igg; cleavage; pf4 ... See more keywords
Most anti-PF4 antibodies in vaccine-induced immune thrombotic thrombocytopenia are transient
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DOI: 10.1182/blood.2021014214
Abstract: Vaccine-induced Thrombotic Thrombocytopenia (VITT)is triggered by vaccination against COVID-19 with adenovirus vectorvaccines (ChAdOx1 nCoV-19; Ad26.COV2-S). In this observational study, we followed VITT patients for changes in their reactivity ofplatelet-activating anti-platelet factor 4 (PF4) IgG antibodiesby… read more here.
Keywords: vaccine induced; pf4; platelet; thrombotic thrombocytopenia ... See more keywords
Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose
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DOI: 10.1182/blood.2022017594
Abstract: Patients with β -thalassemia show 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection, representing a high-risk population compared with age- and sex-matched healthy subjects. 1 Vaccination against SARS-CoV-2 is crucial to reduce mortality and… read more here.
Keywords: aging immune; cov mrna; vaccine; anti pf4 ... See more keywords
Longitudinal Profiles of Anti-Platelet Factor 4 Antibodies in Thai People Who Received ChAdOx1 nCoV-19 Vaccination
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DOI: 10.3390/vaccines11030692
Abstract: Anti-platelet factor 4 (anti-PF4) antibodies were identified as pathogenic antibodies for vaccine-induced immune thrombocytopenia and thrombosis (VITT) in subjects receiving ChAdOx1 nCoV-19 vaccinations. We performed a prospective cohort study to determine the prevalence of anti-PF4… read more here.
Keywords: anti platelet; chadox1 ncov; anti pf4; vaccination ... See more keywords