Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models.
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DOI: 10.1016/j.ejmech.2018.09.033
Abstract: Phosphatidylinositide 3-kinases (PI3Ks) are widely expressed enzymes involved in membrane signalization pathways. Attempts to administer inhibitors with broad activity against different isoforms have failed due to toxicity. Conversely the PI3Kδ isoform is much more selectively… read more here.
Keywords: anti pi3k; compound; preclinical models; atopic ... See more keywords