Comparison of 3 anti-PLA2R inmmunoassaysfor the diagnosis of idiopathic membranous nephropathy in an european population. A pilot study.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical immunology"
DOI: 10.1016/j.clim.2021.108729
Abstract: Membranous nephropathy (MN) is one of the most frequent causes of nephrotic syndrome. Renal biopsy is nowadays the gold standard for the diagnosis of MN. The presence of circulating PLA2R antibody is a very specific… read more here.
Keywords: membranous nephropathy; anti pla2r; pilot study; diagnosis ... See more keywords
Detection of urinary podocytes by flow cytometry in idiopathic membranous nephropathy
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DOI: 10.1038/s41598-020-73335-2
Abstract: Idiopathic membranous nephropathy (iMN) is considered an immune-mediated disease where circulating autoantibodies against podocyte targets (mainly the PLA2R) cause the deposition of in-situ subepithelial immune-complexes. The consequent podocyte damage may cause cell detachment in urine… read more here.
Keywords: anti pla2r; membranous nephropathy; idiopathic membranous; flow cytometry ... See more keywords
Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2039705
Abstract: Abstract Background The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction. The… read more here.
Keywords: pla2r antibodies; anti pla2r; damage; pla2r ... See more keywords
Association of serum mannose-binding lectin, anti-phospholipase A2 receptor antibody and renal outcomes in idiopathic membranous nephropathy and atypical membranous nephropathy: a single center retrospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2048016
Abstract: Abstract Objectives Idiopathic membranous nephropathy (iMN) is a major cause of nephrotic syndrome. Atypical membranous nephropathy (aMN) is a new type of nephropathy in China, characterized by a ‘full-house’ on immunofluorescent examination, that is IgG,… read more here.
Keywords: idiopathic membranous; anti pla2r; atypical membranous; membranous nephropathy ... See more keywords
Anti-PLA2R antibody measured by ELISA predicts the risk of vein thrombosis in patients with primary membranous nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2057861
Abstract: Abstract Background Primary membranous nephropathy (PMN) is associated with the highest risk for developing venous thrombosis compared with other nephrotic diseases. The aim of the study was to assess the predictive value of the pathognomonic… read more here.
Keywords: venous thrombosis; thrombosis; pla2r antibody; anti pla2r ... See more keywords
Comparison of 2 Anti-PLA2R Immunoassays for the Diagnosis of Primary Membranous Nephropathy
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DOI: 10.1093/labmed/lmy016
Abstract: Background Anti-phospholipase A2 receptor (anti-PLA2R) is a promising biomarker for diagnosis, activity evaluation, therapy monitoring, and prognostic estimation of primary membranous neuropathy (pMN). Difference in methodology may be one cause of the discrepancy in anti-PLA2R-positive… read more here.
Keywords: primary membranous; anti pla2r; pla2r; iif elisa ... See more keywords
MO300PHOSPHOLIPASE A2 RECEPTOR ANTIBODY SCREENING IN NEPHROTIC SYNDROME MAY IDENTIFY A DISTINCT SUBSET OF PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab104.0058
Abstract: Primary membranous nephropathy (MN) is a glomerulus-specific autoimmune disorder caused by anti-phospholipase A2 receptor (anti-PLA2R) antibodies in 70-80% of cases. We sought to investigate the utility of anti-PLA2R antibody as a non-invasive screening method for… read more here.
Keywords: diagnosis; titer; anti pla2r; pla2r antibody ... See more keywords
Qualitative and Quantitative Dosage of the Anti M-Type Phospholipase A2 Receptor Autoantibody: One-Year Experience in Quebec’s Reference Center
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DOI: 10.1177/20543581211052729
Abstract: Background: Quantification of the M-type phospholipase A2 receptor antibodies (anti-PLA2R) is now an essential tool for diagnosis and management of primary membranous nephropathy (MN). Since October 2018, Hôpital Maisonneuve-Rosemont (HMR) has been designated as Quebec’s… read more here.
Keywords: year; anti pla2r; quebec; test ... See more keywords
Can use of the serum anti-PLA2R antibody negate the need for a renal biopsy in primary membranous nephropathy?
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DOI: 10.1371/journal.pone.0281726
Abstract: Background Since the emergence of the anti-PLA2R antibody (PLA2R-Ab) test, nephrology practice has not changed dramatically, with most nephrologists still relying on a kidney biopsy to diagnose membranous nephropathy. In this study, we examined the… read more here.
Keywords: anti pla2r; pla2r; pla2r antibody; test ... See more keywords
A Proposal for a Serology-Based Approach to Membranous Nephropathy.
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DOI: 10.1681/asn.2016070776
Abstract: Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by autoantibodies against the recently discovered podocyte antigens: the M-type phospholipase A2 receptor 1 (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A). Assays for quantitative… read more here.
Keywords: serology; anti pla2r; serology based; membranous nephropathy ... See more keywords
Clinical diagnostic performance of common laboratory indicators in primary glomerulonephritis.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202212_30657
Abstract: OBJECTIVE Immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) are common types of primary glomerulonephritis (PGD). A lack of specific clinical features makes diagnosis difficult. Kidney function indicators have been used for their diagnosis. However,… read more here.
Keywords: primary glomerulonephritis; anti pla2r; c1q; diagnostic performance ... See more keywords