Exploration of Anti-plasmodial Activity of Prunus cerasoides Buch.-Ham. ex D. Don (family: Rosaceae) and Its Wood Chromatographic Fractions
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DOI: 10.1007/s11686-020-00272-5
Abstract: Purpose Increasing resistance to the currently available antimalarial drugs is a leading cause of failure to control malaria. Plant-based medicines are commonly used to manage numerous infections, making medicinal plants the best possible source of… read more here.
Keywords: prunus cerasoides; anti plasmodial; activity; plasmodial activity ... See more keywords
Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids.
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DOI: 10.1021/acsmedchemlett.2c00078
Abstract: In the search of new antiplasmodial agents, a multitargeted approach was used in the synthesis of triazolopyrimidine- and 4-aminoquinolines-based hybrids. In vitro antiplasmodial evaluation on chloroquine-sensitive (3D7) and -resistant (W2) P. falciparum strains identified triazolopyrimidine-4-aminoquinoline… read more here.
Keywords: insights aminoquinoline; anti plasmodial; plasmodial activities; activities mechanistic ... See more keywords
Anti-plasmodial activities of Combretum molle (Combretaceae) [Zwoo] seed extract in Swiss albino mice
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DOI: 10.1186/s13104-018-3424-4
Abstract: ObjectiveObjective of the study was to evaluate in vivo anti-plasmodial activities of Combretum molle seed extract.MethodsAs a standard protocol, initially the acute toxicity of the plant seed extract was checked following single administration of crude… read more here.
Keywords: seed; anti plasmodial; plasmodial activities; seed extract ... See more keywords
Nanoincorporation of Plumbagin in Micelles Increase Its in Vivo Anti-Plasmodial Properties
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DOI: 10.18502/ijpa.v17i2.9538
Abstract: Background: The application of plumbagin (PLN), with a wide use in pharmaceutical science, is limited due to its low water solubility and poor bioavailability. Micelles can encapsulate hydrophobic drugs due to their hydrophobic core. The… read more here.
Keywords: anti plasmodial; vivo anti; drug; plumbagin ... See more keywords
Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4253006
Abstract: Malaria is the most lethal parasitic infections in the world. To address the emergence of drug resistance to current antimalarials, here we report the design and synthesis of new series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide hybrids by using… read more here.
Keywords: series tetrahydrobenzothieno; tetrahydrobenzothieno pyrimidine; anti plasmodial; pyrimidine acetamide ... See more keywords
Assessment of toxicity and anti-plasmodial activities of chloroform fractions of Carapa procera and Alchornea cordifolia in murine models
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1077380
Abstract: Background: Plant as a source of medicine has gained international popularity in recent times because of its natural origin, availability in local communities, cheaper to purchase, ease of administration, and its usefulness as an alternative… read more here.
Keywords: carapa procera; chloroform fractions; alchornea cordifolia; anti plasmodial ... See more keywords
Cytotoxic and Anti-Plasmodial Activities of Stephania dielsiana Y.C. Wu Extracts and the Isolated Compounds
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DOI: 10.3390/molecules25163755
Abstract: Natural products remain a viable source of novel therapeutics, and as detection and extraction techniques improve, we can identify more molecules from a broader set of plant tissues. The aim of this study was an… read more here.
Keywords: anti plasmodial; cytotoxic anti; plasmodial activities; stephania dielsiana ... See more keywords
Hematinic, anti-plasmodial potential and toxicity of aqueous leaf extract of Justicia secundain albino mice
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DOI: 10.4314/tjpr.v22i4.13
Abstract: Purpose: To investigate the hematinic, anti-plasmodial potentials, and toxic effects of an aqueous extract of the leaf of Justicia secunda in mice (Mus musculus) made anemic by Plasmodium beighei. Methods: The LD50 of J. secunda… read more here.
Keywords: extract; justicia; anti plasmodial; hematinic anti ... See more keywords