Synthesis and in vitro activities on anti-platelet aggregation of 4-methoxyisophthalamides
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DOI: 10.1007/s00044-018-2207-8
Abstract: A series of 4-methoxyisophthalamides (1d–1w) were designed and synthesized and their chemical structures were confirmed by IR, MS, 1H-NMR, and 13C-NMR. The in vitro on anti-platelet aggregation activities of these compounds were assessed by using… read more here.
Keywords: platelet aggregation; synthesis vitro; anti platelet; vitro activities ... See more keywords
Synthesis, in vitro cytotoxicity and anti-platelet activity of new 1,3-bentzenedisulfonamides
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DOI: 10.1007/s00044-019-02419-0
Abstract: To obtain more active and selective anti-platelet candidate drugs, we tried to introduce a methyl group at the 5-position and 6-position of the parent benzene ring first time, respectively or simultaneously. The idea could inspect… read more here.
Keywords: anti platelet; platelet activity; series; cytotoxicity ... See more keywords
Why Not Dipyridamole: a Review of Current Guidelines and Re-evaluation of Utility in the Modern Era
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DOI: 10.1007/s10557-021-07224-9
Abstract: Dipyridamole is an old anti-platelet and coronary vasodilator agent that inhibits platelet phosphodiesterase and increases interstitial adenosine levels. Its use in coronary artery disease (CAD) has fallen out of practice in the modern era with… read more here.
Keywords: anti platelet; era; utility; review current ... See more keywords
Dual Anti-platelet Therapy After Transcatheter Aortic Valve Implantation: Double Trouble?
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DOI: 10.1007/s10557-021-07296-7
Abstract: Transcatheter aortic valve implantation (TAVI) has emerged over the last decade as a viable treatment option for patients with severe symptomatic aortic stenosis (AS) across all risk strata with TAVI procedural volumes increasing significantly over… read more here.
Keywords: anti platelet; risk; aortic valve; platelet therapy ... See more keywords
Cucurbitacins Elicit Anti-Platelet Activity via Perturbation of the Cytoskeleton and Integrin Function
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DOI: 10.1055/a-1788-5322
Abstract: Cucurbitacins are dietary compounds that have been shown to elicit a range of anti-tumour, anti-inflammatory and anti-atherosclerotic activities. Originally identified as signal transducer and activator of transcription, STAT, inhibitors, a variety of mechanisms of action… read more here.
Keywords: platelet; integrin function; anti platelet; cytoskeleton ... See more keywords
Peri-Procedural Platelet Reactivity in Percutaneous Coronary Intervention.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0038-1649484
Abstract: Platelet activation and aggregation play a pivotal role in thrombotic complications occurring during percutaneous coronary intervention (PCI), and peri-PCI anti-platelet therapy represents a standard of care. High platelet reactivity prior to PCI has been correlated… read more here.
Keywords: anti platelet; platelet reactivity; percutaneous coronary; pci ... See more keywords
Racial Differences in Ischaemia/Bleeding Risk Trade-Off during Anti-Platelet Therapy: Individual Patient Level Landmark Meta-Analysis from Seven RCTs.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0038-1676545
Abstract: BACKGROUND Prolonged dual anti-platelet therapy (DAPT) is intended to reduce ischaemic events, at the cost of an increased bleeding risk in patients undergoing percutaneous coronary intervention (PCI). In this study, we evaluated whether race influences… read more here.
Keywords: risk; anti platelet; east asians; ischaemia bleeding ... See more keywords
Duration of dual anti-platelet therapy – State of the art after the DAPT and PEGASUS-TIMI 54 trials
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DOI: 10.1080/00015385.2017.1305189
Abstract: Abstract Dual anti-platelet therapy is prescribed in the setting of coronary heart disease for the prevention of stent thrombosis and acute thrombotic events. The optimal duration of dual anti-platelet therapy is still under debate as… read more here.
Keywords: anti platelet; dual anti; platelet therapy; duration dual ... See more keywords
Effect of anti-coagulation in elderly patients with atrial fibrillation
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DOI: 10.1093/europace/euab116.105
Abstract: Type of funding sources: None. Atrial fibrillation has been shown to associate with greater cognitive decline and increased dementia risk independent of ischaemic stroke. Anti-coagulation was associated with a lower risk of ischemic stroke and… read more here.
Keywords: anti platelet; atrial fibrillation; elderly patients; oral anti ... See more keywords
Micelle Incorporated Liquid-Chromatography in the Light of Green Chemistry: an Application for the Quality Control Analysis of anti-Platelet Fixed-Dose Combinations.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsac046
Abstract: BACKGROUND Oral anti-platelet agents are the cornerstone of treatment of multiple cardiovascular diseases and in the long-term prevention of their recurrence. OBJECTIVE In the present work, we report a method based on micellar liquid chromatography… read more here.
Keywords: liquid chromatography; chemistry; analysis; anti platelet ... See more keywords
The in vitro bioavailability of anti-platelet peptides in collagen hydrolysate from silver carp (Hypophthalmichthys molitrix) skin.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13226
Abstract: Previous animal experiments indicated collagen hydrolysates (CHs) intake decreased platelet release indicators in plasma and highlight potential applications as healthcare supplements to combat cardiovascular disease. The oligopeptides (GPR, GPRG, and GPRGP) have anti-platelet activities. However,… read more here.
Keywords: anti platelet; silver carp; bioavailability; gprg gprgp ... See more keywords