Anti-prion Butenolides and Diphenylpropanones from the Australian Ascidian Polycarpa procera.
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DOI: 10.1021/acs.jnatprod.9b00551
Abstract: A library of 500 Australian marine invertebrate extracts was screened for anti-prion activity using a yeast-based assay, and this resulted in an extract from the ascidian Polycarpa procera showing potent activity. Purification of this extract… read more here.
Keywords: prion; anti prion; ascidian polycarpa; polycarpa procera ... See more keywords
Anti-Prion Systems Block Prion Transmission, Attenuate Prion Generation, Cure Most Prions as They Arise and Limit Prion-Induced Pathology in Saccharomyces cerevisiae
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DOI: 10.3390/biology11091266
Abstract: Simple Summary Virus and bacterial infections are opposed by their hosts at many levels. Similarly, we find that infectious proteins (prions) are severely restricted by an array of host systems, acting independently to prevent infection,… read more here.
Keywords: prion; pathology; anti prion; prion systems ... See more keywords
Ethanolamine Is a New Anti-Prion Compound
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DOI: 10.3390/ijms222111742
Abstract: Prion diseases are a group of fatal neurodegenerative disorders caused by accumulation of proteinaceous infectious particles, or prions, which mainly consist of the abnormally folded, amyloidogenic prion protein, designated PrPSc. PrPSc is produced through conformational… read more here.
Keywords: dmem; prion compound; prion; new anti ... See more keywords
Prion Variants of Yeast are Numerous, Mutable, and Segregate on Growth, Affecting Prion Pathogenesis, Transmission Barriers, and Sensitivity to Anti-Prion Systems
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DOI: 10.3390/v11030238
Abstract: The known amyloid-based prions of Saccharomyces cerevisiae each have multiple heritable forms, called “prion variants” or “prion strains”. These variants, all based on the same prion protein sequence, differ in their biological properties and their… read more here.
Keywords: variants yeast; prion; prion systems; anti prion ... See more keywords
Anti-Prion Systems in Saccharomyces cerevisiae Turn an Avalanche of Prions into a Flurry
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DOI: 10.3390/v14091945
Abstract: Prions are infectious proteins, mostly having a self-propagating amyloid (filamentous protein polymer) structure consisting of an abnormal form of a normally soluble protein. These prions arise spontaneously in the cell without known reason, and their… read more here.
Keywords: prion; systems saccharomyces; saccharomyces cerevisiae; prion variants ... See more keywords