Curcumin Conjugates of Non‐steroidal Anti‐Inflammatory Drugs: Synthesis, Structures, Anti‐proliferative Assays, Computational Docking, and Inflammatory Response
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DOI: 10.1002/open.202000173
Abstract: Abstract In an effort to combine the anti‐proliferative effect of CUR‐BF2 and CUR compounds with anti‐inflammatory benefits of non‐steroidal anti‐inflammatory drugs (NSAIDs), a library of the bis‐ and mono‐NSAID/CUR‐BF2 and NSAID/CUR conjugates were synthesized by… read more here.
Keywords: anti inflammatory; cur bf2; anti proliferative; nsaid cur ... See more keywords
The uses of cyclohexan-1,4-dione for the synthesis of thiophene derivatives as new anti-proliferative, prostate anticancer, c-Met and tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2087-3
Abstract: A series of heterocyclic compounds derived from the dihydrobenzo[b]thiophene derivatives were synthesized all the synthesized compounds were determined by elemental analysis, 1H NMR, 13C NMR, and MS. The newly synthesized compounds were evaluated for their… read more here.
Keywords: anti proliferative; kinase; thiophene derivatives; uses cyclohexan ... See more keywords
Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-03107-7
Abstract: Purpose Glioblastoma multiforme (GBM) is a poorly curable disease due to its profound chemoresistance. Despite recent advances in surgery, radiotherapy and chemotherapy, the efficient treatment of GBMs is still a clinical challenge. Beside others, AT101,… read more here.
Keywords: anti proliferative; treatment; human primary; treatment at101 ... See more keywords
Ginseng fermented by mycotoxin non-producing Aspergillus niger: ginsenoside analysis and anti-proliferative effects
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DOI: 10.1007/s10068-017-0117-z
Abstract: Korean ginseng was fermented using Aspergillus niger (A. niger) FMB S494 and mycotoxins such as ochratoxin and fumonisin were not detected in the fermented ginseng. Protopanaxadiol-type ginsenosides such as glycosylated forms of Rb1, Rb2, Rc,… read more here.
Keywords: aspergillus niger; 104 ppm; anti proliferative; ginseng ... See more keywords
Synthesis, characterization and molecular docking studies of thiouracil derivatives as potent thymidylate synthase inhibitors and potential anticancer agents
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DOI: 10.1007/s11030-017-9776-1
Abstract: Thymidylate synthase (TS), one of folate-dependent enzymes, is a key and well-recognized target for anticancer agents. In this study, a series of 6-aryl-5-cyano thiouracil derivatives were designed and synthesized in accordance with essential pharmacophoric features… read more here.
Keywords: anti proliferative; anticancer agents; thymidylate synthase; thiouracil derivatives ... See more keywords
Mannich aminomethylation of flavonoids and anti-proliferative activity against breast cancer cell
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DOI: 10.1007/s11696-018-0402-1
Abstract: We herein report Mannich aminomethylation of variously structural flavonoids and their biological evaluation against human breast cancer cell. Mannich reaction showed that substitution at C-6 position depends on amine basicity and C-ring feature of flavonoids.… read more here.
Keywords: anti proliferative; aminomethylation; breast cancer; cancer cell ... See more keywords
Behavioral conditioning of anti-proliferative and immunosuppressive properties of the mTOR inhibitor rapamycin
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.04.013
Abstract: Suppression of immune functions can be elicited by behavioral conditioning using drugs such as cyclosporine A, cyclophosphamide, or opioids. Nevertheless, little is known regarding the conditioned actions of clinically approved immunosuppressive drugs with distinct cell… read more here.
Keywords: immunosuppressive properties; anti proliferative; proliferative immunosuppressive; behavioral conditioning ... See more keywords
Evaluation of antioxidant and anti-proliferative efficacy of Nostoc muscorum NCCU-442
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DOI: 10.1016/j.bcab.2018.12.001
Abstract: Abstract Natural sources have always been the primary sources of bioactive principles. Cyanobacteria with its wide spectrum of metabolites represents a favourable source of compounds having medicinal properties like antioxidant, anti-proliferative etc. In this study… read more here.
Keywords: anti proliferative; nostoc muscorum; antioxidant anti; phenolic content ... See more keywords
Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.038
Abstract: Quinoline derivatives 2, 3, quinolinyl based pyrazolines 4a,b, 5 and quinolinyl pyrazolinyl thiazole hybrids 6a-d, 7a-c and 8a-d were synthesized and screened for their anti-proliferative activity against MCF-7, HeLa and DLD1 cancer cell lines as… read more here.
Keywords: anti proliferative; egfr inhibitors; quinoline; thiazole hybrids ... See more keywords
Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation.
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DOI: 10.1016/j.bioorg.2021.105105
Abstract: VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a new series of quinoxaline-2(1H)-one derivatives were designed and synthesized. The synthesized compounds were tested against three human cancer cell lines… read more here.
Keywords: anti proliferative; hct 116; cell lines; quinoxaline one ... See more keywords
4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.
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DOI: 10.1016/j.bioorg.2021.105349
Abstract: A series of fluorinated and hydroxylated 2,4-diphenyl indenopyridinols were designed and synthesized using l-proline-catalyzed and microwave-assisted synthetic methods for the development of new anticancer agents. Adriamycin and etoposide were used as reference compounds for the… read more here.
Keywords: anti proliferative; chemistry; inhibitory; structure ... See more keywords