Antipsychotic clozapine binding to alpha-2-macroglobulin protects interacting partners against oxidation and preserves the anti-proteinase activity of the protein.
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DOI: 10.1016/j.ijbiomac.2021.04.155
Abstract: In this study, the interaction between clozapine, an atypical antipsychotic drug, and alpha-2-macroglobulin (α2M), a multipurpose anti-proteinase, was investigated under simulated (patho) physiological conditions using multiple spectroscopic techniques and molecular modeling. It was found that… read more here.
Keywords: proteinase activity; anti proteinase; clozapine; alpha macroglobulin ... See more keywords