Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.011
Abstract: Human dihydroorotate dehydrogenase (hDHODH) is a flavin-dependent enzyme essential to pyrimidine de novo biosynthesis, which serves as an attractive therapeutic target for the treatment of autoimmune disorders. A novel series of hDHODH inhibitors was developed… read more here.
Keywords: novel series; series hdhodh; hdhodh inhibitors; chemistry ... See more keywords
New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum Nakai
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Journal of Natural Medicines"
DOI: 10.1016/s1875-5364(21)60116-4
Abstract: Four new prenylflavonoid glycosides, namely koreanoside H-K ( 1 - 4 ), together with eleven known ones ( 5 – 15 ) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated… read more here.
Keywords: prenylflavonoid glycosides; pulmonary fibrosis; anti pulmonary; epimedium koreanum ... See more keywords
Nintedanib exerts anti-pulmonary fibrosis activity via inhibiting TANK-binding kinase 1 (TBK1) phosphorylation.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc05621b
Abstract: Since triple angiokinase inhibitor could not fully explain the anti-pulmonary fibrosis activity of nintedanib (NDNB), the chemoproteomic strategy was performed to identify TANK-binding kinase 1 (TBK1) as the key target of NDNB in human pulmonary… read more here.
Keywords: tbk1; fibrosis activity; pulmonary fibrosis; fibrosis ... See more keywords
β-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGF-β/Smad Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.947226
Abstract: Pulmonary fibrosis is a scarring disease of lung tissue, which seriously threatens human health. Treatment options are currently limited, and effective strategies are still lacking. In the present study, 25 compounds were isolated from the… read more here.
Keywords: sea fungus; deep sea; pulmonary fibrosis; fibrosis ... See more keywords
Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154870
Abstract: Five new triterpenoids, oenotheralanosterols C-G (1–5), with seven known triterpenoidcompounds, namely 2α,3α,19α-trihydroxy-24-norurs4,12-dien-28-oic acid (6), 3β,23-dihydroxy-1-oxo-olean-12-en-28-oic acid (7), remangilone C (8), knoxivalic acid A (9), termichebulolide (10), rosasecotriterpene A (11), androsanortriterpene C (12), were extracted and… read more here.
Keywords: pulmonary fibrosis; oenothera biennis; anti pulmonary; fibrosis activities ... See more keywords