Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113823
Abstract: Schistosomiasis is a neglected disease of poverty that is caused by infection with blood fluke species contained within the genus Schistosoma. For the last 40 years, control of schistosomiasis in endemic regions has predominantly been… read more here.
Keywords: chemistry; activities quinoxaline; compound; schistosomal activities ... See more keywords
Anti-schistosomal action of the calcium channel agonist FPL-64176
Sign Up to like & getrecommendations! Published in 2019 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2019.08.006
Abstract: Subversion of parasite neuromuscular function is a key strategy for anthelmintic drug development. Schistosome Ca2+ signaling has been an area of particular interest for decades, with a specific focus on L-type voltage-gated Ca2+ channels (Cavs).… read more here.
Keywords: action calcium; anti schistosomal; schistosomal action; fpl 64176 ... See more keywords
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities
Sign Up to like & getrecommendations! Published in 2020 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.16069.2
Abstract: Background: Schistosomiasis, caused by infection with blood fluke schistosomes, is a neglected tropical disease of considerable importance in resource-poor communities throughout the developing world. In the absence of an immunoprophylactic vaccine and due to over-reliance… read more here.
Keywords: smp 138030; identification piperazin; anti schistosomal; 138030 smmll ... See more keywords
Identification of anti-schistosomal, anthelmintic and anti-parasitic compounds curated and text-mined from the scientific literature
Sign Up to like & getrecommendations! Published in 2022 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.17987.1
Abstract: More than a billion people are infected with parasitic worms, including nematodes, such as hookworms, and flatworms, such as blood flukes. Few drugs are available to treat worm infections, but high-throughput screening approaches hold promise… read more here.
Keywords: parasitic compounds; anthelmintic anti; anti parasitic; anti schistosomal ... See more keywords
Anti-schistosomal immunity to core xylose/fucose in N-glycans
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1142620
Abstract: Schistosomiasis is a globally prevalent, debilitating disease that is poorly controlled by chemotherapy and for which no vaccine exists. While partial resistance in people may develop over time with repeated infections and treatments, some animals,… read more here.
Keywords: xyl fuc; core; brown rat; anti schistosomal ... See more keywords