The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04212-8
Abstract: Suppression of therapeutic transgene expression from retroviral gene therapy vectors by epigenetic defence mechanisms represents a problem that is particularly encountered in pluripotent stem cells (PSCs) and their differentiated progeny. Transgene expression in these cells,… read more here.
Keywords: cpg sites; ubiquitous chromatin; anti silencing; chromatin opening ... See more keywords
Insights into transcriptional silencing and anti‐silencing in Shigella flexneri: a detailed molecular analysis of the icsP virulence locus
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DOI: 10.1111/mmi.13932
Abstract: Transcriptional silencing and anti‐silencing mechanisms modulate bacterial physiology and virulence in many human pathogens. In Shigella species, many virulence plasmid genes are silenced by the histone‐like nucleoid structuring protein H‐NS and anti‐silenced by the virulence… read more here.
Keywords: transcriptional silencing; virulence; anti silencing; shigella ... See more keywords
Knockdown of anti-silencing function 1B histone chaperone induces cell apoptosis via repressing PI3K/Akt pathway in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Oncology"
DOI: 10.3892/ijo.2018.4526
Abstract: Prostate cancer (PCa) is one of the most common malignancies among males worldwide. Anti-silencing function 1B histone chaperone (ASF1B) has been reported to be involved in PCa. The present study aimed to investigate the role… read more here.
Keywords: prostate cancer; asf1b; pca; anti silencing ... See more keywords
Anti-silencing function 1B promotes the progression of pancreatic cancer by activating c-Myc
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DOI: 10.3892/ijo.2022.5456
Abstract: The present study aimed to explore the role of histone chaperone anti-silencing function 1B (ASF1B) in pancreatic cancer and the underlying mechanism. The biological function of ASF1B was investigated in pancreatic cancer cell lines (PANC-1… read more here.
Keywords: silencing function; anti silencing; pancreatic cancer; activating myc ... See more keywords
Anti-silencing function 1B knockdown suppresses the malignant phenotype of colorectal cancer by inactivating the phosphatidylinositol 3-kinase/AKT pathway
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastrointestinal Oncology"
DOI: 10.4251/wjgo.v14.i12.2353
Abstract: BACKGROUND Mounting studies have highlighted the pivotal influence of anti-silencing function 1B (ASF1B) on the malignancy of cancers. AIM To explore the influence and mechanism of ASF1B in colorectal cancer (CRC). METHODS Quantitative real-time polymerase… read more here.
Keywords: silencing function; anti silencing; phosphatidylinositol kinase; crc ... See more keywords