Alanine transaminase is predominantly increased in the active phase of anti-HMGCR myopathy
Sign Up to like & getrecommendations! Published in 2022 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2021.10.007
Abstract: Autoantibodies against 3‑hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and the signal recognition particle (SRP) are representative antibodies causing immune-mediated necrotizing myopathies (IMNM), called as anti-HMGCR and anti-SRP myopathies, respectively. Here, we analyzed the differences in routine blood test… read more here.
Keywords: anti; hmgcr; hmgcr myopathy; anti srp ... See more keywords
Immune-mediated necrotizing myopathy: clinical features and pathogenesis
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DOI: 10.1038/s41584-020-00515-9
Abstract: Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA reductase (anti-HMGCR) myositis-specific autoantibodies, although ~20% of… read more here.
Keywords: muscle; imnm; mediated necrotizing; immune mediated ... See more keywords
Daratumumab as a rescue therapy in severe refractory anti-SRP immune-mediated necrotising myopathy
Sign Up to like & getrecommendations! Published in 2023 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2022-223541
Abstract: REFERENCES 1 Petri M, Landy H, Clowse MEB, et al. Belimumab use during pregnancy: a summary of birth defects and pregnancy loss from belimumab clinical trials, a pregnancy registry and postmarketing reports. Ann Rheum Dis… read more here.
Keywords: anti srp; daratumumab rescue; therapy severe; severe refractory ... See more keywords
Anti-SRP immune-mediated necrotizing myopathy: A critical review of current concepts
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DOI: 10.3389/fimmu.2022.1019972
Abstract: Purpose of review This review aims to describe clinical and histological features, treatment, and prognosis in patients with anti-signal recognition particle (SRP) autoantibodies positive immune-mediated necrotizing myopathy (SRP-IMNM) based on previous findings. Previous findings Anti-SRP… read more here.
Keywords: anti srp; srp imnm; srp; review ... See more keywords
Predictors of cardiac involvement in idiopathic inflammatory myopathies
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DOI: 10.3389/fimmu.2023.1146817
Abstract: Objectives Idiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. Methods Multicenter, open cohort study, including patients registered… read more here.
Keywords: anti srp; idiopathic inflammatory; involvement; predictors cardiac ... See more keywords