Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30421-w
Abstract: Incomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their application is… read more here.
Keywords: l2a5 specifically; antibody; novel monoclonal; cancer ... See more keywords
Sialyl-Tn serves as a potential therapeutic target for ovarian cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-024-01397-1
Abstract: Ovarian cancer remains the deadliest of the gynecologic cancers in the United States. There have been limited advances in treatment strategies that have seen marked increases in overall survival. Thus, it is essential to continue… read more here.
Keywords: anti stn; ovarian cancer; cancer; stn adc ... See more keywords