Anti-trypanosomal activity of doubly modified salinomycin derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.03.061
Abstract: As a group of biologically active compounds, polyether antibiotics (ionophores) show a broad spectrum of interesting pharmacological properties, ranging from anti-bacterial to anti-cancer activities. There is increasing evidence that ionophores, including salinomycin (SAL), and their… read more here.
Keywords: trypanosomal activity; sal; doubly modified; anti trypanosomal ... See more keywords
Naphthoquinone derivatives exhibit apoptosis-like effect and anti-trypanosomal activity against Trypanosoma evansi.
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2021.109367
Abstract: Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and have been used for the treatment of animal trypanosomosis, but they… read more here.
Keywords: trypanosomal activity; activity; effect; anti trypanosomal ... See more keywords
Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis
Sign Up to like & getrecommendations! Published in 2020 at "Tropical Medicine and Infectious Disease"
DOI: 10.3390/tropicalmed5010028
Abstract: Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of… read more here.
Keywords: trypanosomiasis; proteasome inhibitors; african trypanosomiasis; anti trypanosomal ... See more keywords
Anti-trypanosomal activity of secnidazole in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v16i3.6
Abstract: Purpose : To evaluate the anti-trypanosomal effect of secnidazole (SEC) in vitro and in vivo. Methods: The dose-response effect of SEC in Trypanosoma b. brucei infected rats was evaluated in five groups of rats (n… read more here.
Keywords: vitro vivo; sec; secnidazole; effect ... See more keywords