Discovery of Anti‐tubercular Analogues of Bedaquiline with Modified A‐, B‐ and C‐Ring Subunits
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200533
Abstract: To date, the clinical use of the anti‐tubercular therapy bedaquiline has been somewhat limited due to safety concerns. Recent investigations determined that modification of the B‐ and C‐ring units of bedaquiline delivered new diarylquinolines (for… read more here.
Keywords: anti tubercular; tubercular activity; ring units; within bedaquiline ... See more keywords
Repositioning of Isatin hybrids as novel anti-tubercular agents overcoming pre-existing antibiotics resistance
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02699-5
Abstract: The widespread deaths of tuberculosis from many decades demands an urgent need for the development of novel anti-tubercular scaffolds that are more potent and highly selective with lower cytotoxicity. Isatin hybrids are endowed with an… read more here.
Keywords: novel anti; anti tubercular; hybrids novel; repositioning isatin ... See more keywords
Hematuria and proteinuria in a 14-year-old boy on anti-tubercular treatment: Questions
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Nephrology"
DOI: 10.1007/s00467-022-05435-2
Abstract: A 14-year-old South Indian Tamilian boy, who was born to non-consanguineous parents, was referred to us with complaints of cola-colored urine, periorbital puffiness, swelling of feet, decreased urine output, and rash over bilateral lower limbs… read more here.
Keywords: tubercular treatment; lower limbs; year old; anti tubercular ... See more keywords
Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10108-z
Abstract: As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids (7a–l) were efficiently synthesized in excellent yields by the popular ‘Fisher–Indole synthesis’ approach. The structure elucidation of… read more here.
Keywords: tubercular agents; fused spirochromenes; anti tubercular; synthesis ... See more keywords
Development and validation of consensus machine learning-based models for the prediction of novel small molecules as potential anti-tubercular agents.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10238-y
Abstract: Tuberculosis (TB) is an infectious disease and the leading cause of death globally. The rapidly emerging cases of drug resistance among pathogenic mycobacteria have been a global threat urging the need of new drug discovery… read more here.
Keywords: machine learning; validation; small molecules; anti tubercular ... See more keywords
Synthesis and evaluation of novel coumarin-oxime ethers as potential anti-tubercular agents: Their DNA cleavage ability and BSA interaction study.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.042
Abstract: As a contribution to the development of novel coumarin-oxime ether conjugates with therapeutically interesting properties, a series of coumarin-oxime ether (1a-1j) was synthesised using SN2 reaction of bromomethyl coumarins with butane-2,3-dione monoxime. Invitro anti-tuberculosis activityagainstMTBH37Rv… read more here.
Keywords: novel coumarin; coumarin oxime; anti tubercular;
Synthesis and biological evaluation of dihydroquinoline carboxamide derivatives as anti-tubercular agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.046
Abstract: Sodium trifluoromethanesulfonate, and glacial acetic acid selectively catalyzed the synthesis of dihydroquinoline via Friedländer annulation. The synthesized dihydroquinoline analogues coupled with different amines by the use of coupling reagent gave dihydroquinoline carboxamide derivatives in moderate… read more here.
Keywords: carboxamide derivatives; anti tubercular; dihydroquinoline carboxamide; synthesis biological ... See more keywords
Synthesis of anti-tubercular marine alkaloids denigrins A and B
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.06.013
Abstract: Abstract The first synthesis of anti-tubercular marine alkaloids denigrins A and B were accomplished in three and five steps and 62% and 31% overall yields respectively, from maleic anhydride. The key features of the synthesis… read more here.
Keywords: marine alkaloids; synthesis anti; anti tubercular; alkaloids denigrins ... See more keywords
Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra01348j
Abstract: Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among… read more here.
Keywords: substituted pyrazine; tubercular agents; piperazine homopiperazine; anti tubercular ... See more keywords
Silica catalyzed one pot synthesis of hybrid thiazolidin-4-one derivatives as anti-tubercular and anti-inflammatory agent by attenuating COX-2 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1643485
Abstract: Abstract A novel series of a hybrid class of hybrid thiazolidin-4-one derivatives were designed and synthesized through one-pot catalytic synthesis. The reaction was catalyzed in the presence of silica-H2SO4(+6). The derivatives computational ADMET profile was… read more here.
Keywords: anti inflammatory; thiazolidin one; one derivatives; hybrid thiazolidin ... See more keywords
Pattern of Recurrent Inflammation following Anti-tubercular Therapy for Ocular Tuberculosis.
Sign Up to like & getrecommendations! Published in 2020 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2020.1772838
Abstract: PURPOSE To investigate recurrence patterns following anti-tubercular therapy (ATT) in different anatomical presentations of ocular tuberculosis (OTB). METHODS Retrospective analysis of clinically diagnosed OTB patients divided anatomically into groups A (anterior + intermediate uveitis) and… read more here.
Keywords: tubercular therapy; recurrent inflammation; inflammation; anti tubercular ... See more keywords