In vitro and in vivo local tolerability of a synergistic anti‐tuberculosis drug combination intended for pulmonary delivery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4381
Abstract: A drug combination, vancomycin (VAN) plus tetrahydrolipstatin (THL), has demonstrated an effective synergistic action in vitro against Mycobacterium tuberculosis (Mtb). The poor oral bioavailability of VAN and THL and the predominant tropism of Mtb infection… read more here.
Keywords: local tolerability; van; anti tuberculosis; combination ... See more keywords
CYP2S1 rs338599 polymorphism confers reduced risk to anti‐tuberculosis drug‐induced liver injury and may be a novel marker for its risk prediction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24478
Abstract: In the present study, we would like to explore whether Cytochrome P450 2S1 (CYP2S1) rs338599 polymorphism confers risk to anti‐tuberculosis drug‐induced liver injury (ADLI) and provide evidence of being used as novel marker for ADLI… read more here.
Keywords: anti tuberculosis; rs338599 polymorphism; polymorphism confers; risk ... See more keywords
Lipid peroxidation aggravates anti-tuberculosis drug-induced liver injury: Evidence of ferroptosis induction.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.09.140
Abstract: Anti-tuberculosis drug-induced liver injury (ATB-DILI) is a common adverse reaction of anti-tuberculosis drug treatment. Studies have shown that isoniazid (INH) and rifampicin (RFP) are mainly metabolized in the liver and a large amount of intracellular… read more here.
Keywords: atb dili; lipid peroxidation; peroxidation; ferroptosis ... See more keywords
Comparison of the predictive outcomes for anti-tuberculosis drug-induced hepatotoxicity by different machine learning techniques
Sign Up to like & getrecommendations! Published in 2020 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2019.105307
Abstract: BACKGROUND The study compared the predictive outcomes of artificial neural network, support vector machine and random forest on the occurrence of anti-tuberculosis drug-induced hepatotoxicity. METHODS The clinical and genomic data of patients treated with anti-tuberculosis… read more here.
Keywords: machine; induced hepatotoxicity; tuberculosis drug; drug induced ... See more keywords
Therapeutic effect of an anti-tuberculosis agent, isoniazid, and its nano-isoform in ulcerative colitis.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107577
Abstract: BACKGROUND Isoniazid (INH) is well known as a first-line anti-tuberculosis, while some studies demonstrate that it has anti-inflammatory activity via a different mechanism such as inhibitionthe production of IL-1, ROS, activation of PPARγ expression, inhibition… read more here.
Keywords: inh; therapeutic effect; colitis; ulcerative colitis ... See more keywords
The "proletarian disease" on stage Theatrical anti-tuberculosis propaganda in the early Soviet Union.
Sign Up to like & getrecommendations! Published in 2021 at "Microbes and infection"
DOI: 10.1016/j.micinf.2021.104838
Abstract: The present contribution analyses sanitary theatrical performances as a means of anti-tuberculosis propaganda in the early Soviet Union. Starting in the 1920s, sanitary theatrical performances were demonstrated in open-air theatres and clubhouses for workers and… read more here.
Keywords: early soviet; soviet union; tuberculosis; tuberculosis propaganda ... See more keywords
Efficacy and tolerability of desensitization in the treatment of delayed drug hypersensitivities to anti-tuberculosis medications.
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2018.12.017
Abstract: BACKGROUND Delayed drug hypersensitivity to first-line anti-tuberculosis medication is a major challenge in tuberculosis treatment. OBJECTIVE This study was performed to investigate the efficacy/tolerability of desensitization therapy in treatment of first-line anti-tuberculosis medication hypersensitivity and… read more here.
Keywords: treatment; delayed drug; tuberculosis; desensitization ... See more keywords
Transforming growth factor-beta 1 polymorphisms and anti-tuberculosis drug-induced liver injury. Polymorphisms in TGFβ1 and its relationship with anti-tuberculosis drug-induced liver injury.
Sign Up to like & getrecommendations! Published in 2019 at "Therapie"
DOI: 10.1016/j.therap.2018.07.003
Abstract: AIM There is evidence to suggest that transforming growth factor-beta 1 takes part in a series of physiological and pathological processes in the human body, including wound healing, tissue fibrosis and embryonic development. We hypothesized… read more here.
Keywords: growth factor; factor beta; anti tuberculosis; transforming growth ... See more keywords
The utility of pharmacokinetic studies for the evaluation of exposure-response relationships for standard dose anti-tuberculosis drugs.
Sign Up to like & getrecommendations! Published in 2018 at "Tuberculosis"
DOI: 10.1016/j.tube.2017.11.004
Abstract: Tuberculosis (TB) is a major public health problem. Many countries still fall below the minimum World Health Organization (WHO) TB treatment target success rate. There is conflicting evidence about whether concentrations of anti-tuberculosis drugs given… read more here.
Keywords: tuberculosis drugs; treatment; utility pharmacokinetic; tuberculosis ... See more keywords
Analysis of Approaches to Anti-tuberculosis Compounds
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03177
Abstract: Mycobacterium tuberculosis (Mtb) remains a deadly pathogen two decades after the announcement of tuberculosis (TB) as a global health emergency by the World Health Organization. Medicinal chemistry efforts to synthesize potential drugs to shorten TB… read more here.
Keywords: approaches anti; analysis approaches; tuberculosis compounds; chemistry ... See more keywords
Impact of nicotine replacement therapy as an adjunct to anti-tuberculosis treatment and behaviour change counselling in newly diagnosed pulmonary tuberculosis patients: an open-label, randomised controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-26990-5
Abstract: We evaluated the impact of intensive smoking cessation activities as an adjunct to anti-tuberculosis treatment on patient-related treatment outcomes. In this open-label, randomised controlled trial, self-reporting smokers with pulmonary tuberculosis who initiated standard anti-tuberculosis treatment… read more here.
Keywords: replacement therapy; treatment; nicotine replacement; tuberculosis treatment ... See more keywords