Structure activity relationships (SAR) study to design and synthesize new tubulin inhibitors with enhanced anti-tubulin activity: In silico and in vitro analysis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129204
Abstract: Abstract Tubulysin family of natural products is a class of highly cytotoxic tetrapeptides that induce apoptosis by arresting the mitosis of a cell. In this article, we have analysed 49 reported tubulysin derivatives with known… read more here.
Keywords: anti tubulin; activity relationships; structure activity; tubulin ... See more keywords
Synthesis, Fungicidal Activity, and Molecular Docking of 2-Acylamino and 2-Thioacylamino Derivatives of 1H-benzo[d]imidazoles as Anti-Tubulin Agents.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c03325
Abstract: This work deals with the synthesis and evaluation of fungicidal activity of benzimidazole derivatives, which are structural analogues of commercial anti-tubulin fungicides. A number of N-acyl and N-thioacyl derivatives of 2-amino-1H-benzo[d]imidazole were prepared, and their… read more here.
Keywords: anti tubulin; docking; fungicidal activity; activity molecular ... See more keywords
Circulating immune complexome analysis identified anti-tubulin-α-1c as an inflammation associated autoantibody with promising diagnostic value for Behcet’s Disease
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DOI: 10.1371/journal.pone.0199047
Abstract: Background Behcet’s disease (BD) is a chronic, multisystem-involved vasculitis and its pathogenesis remains elusive. No specific serological markers for BD diagnosis have been established. Identification of novel diagnostic biomarkers will be helpful in timely diagnostic… read more here.
Keywords: anti tubulin; behcet disease; analysis; immune complexome ... See more keywords