Nanotheranostics with Radionuclides for Cancer Diagnosis and Therapy
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DOI: 10.1002/adfm.202423445
Abstract: Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, with a focus on the design of… read more here.
Keywords: therapy; nanotheranostics radionuclides; cancer diagnosis; diagnosis therapy ... See more keywords
Targeted Inhibition of Tumor Extracellular Vesicle Secretion Improving the Anti‐Tumor Immunity of Lymph Node‐Targeted Vaccines
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DOI: 10.1002/adfm.202504852
Abstract: The combined immunotherapy of tumor vaccine and immune checkpoint blockade (ICB) has shown promising therapeutic benefits in tumor treatment. Notably, the off‐target effects of immune checkpoint inhibitors and their immune‐related adverse events (irAEs) seriously affect… read more here.
Keywords: tumor extracellular; tumor; anti tumor; secretion ... See more keywords
Anti‐Tumor Strategies Targeting Nutritional Deprivation: Challenges and Opportunities
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DOI: 10.1002/adma.202415550
Abstract: Higher and richer nutrient requirements are typical features that distinguish tumor cells from AU: cells, ensuring adequate substrates and energy sources for tumor cell proliferation and migration. Therefore, nutrient deprivation strategies based on targeted technologies… read more here.
Keywords: deprivation; strategies targeting; tumor cells; tumor ... See more keywords
Low Dose Soft X‐Ray Remotely Triggered Lanthanide Nanovaccine for Deep Tissue CO Gas Release and Activation of Systemic Anti‐Tumor Immunoresponse
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DOI: 10.1002/advs.202004391
Abstract: Abstract Gas‐based therapy has emerged as a new green therapy strategy for anti‐tumor treatment. However, the therapeutic efficacy is still restricted by the deep tissue controlled release, poor lymphocytic infiltration, and inherent immunosuppressive tumor microenvironment… read more here.
Keywords: deep tissue; anti tumor; soft ray; tumor ... See more keywords
Nanobody‐Engineered Biohybrid Bacteria Targeting Gastrointestinal Cancers Induce Robust STING‐Mediated Anti‐Tumor Immunity
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DOI: 10.1002/advs.202401905
Abstract: Bacteria can be utilized for cancer therapy owing to their preferential colonization at tumor sites. However, unmodified non‐pathogenic bacteria carry potential risks due to their non‐specific targeting effects, and their anti‐tumor activity is limited when… read more here.
Keywords: engineered biohybrid; tumor; anti tumor; biohybrid bacteria ... See more keywords
Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment
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DOI: 10.1002/advs.202403423
Abstract: B cells are crucial component of humoral immunity, and their role in the tumor immune microenvironment (TME) has garnered significant attention in recent years. These cells hold great potential and application prospects in the field… read more here.
Keywords: tumor immune; checkpoints cells; tumor; cell ... See more keywords
Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity
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DOI: 10.1002/advs.202404442
Abstract: The small G protein Arf1 has been identified as playing a selective role in supporting cancer stem cells (CSCs), making it an attractive target for cancer therapy. However, the current Arf1 inhibitors have limited translational… read more here.
Keywords: cancer; arf1 inhibitors; stem; cancer stem ... See more keywords
A DNA‐Modularized STING Agonist with Macrophage‐Selectivity and Programmability for Enhanced Anti‐Tumor Immunotherapy (Adv. Sci. 32/2024)
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DOI: 10.1002/advs.202470189
Abstract: Cancer Immunotherapy A modularized DNA nanodevice agonist (DNDA) is meticulously designed to function as both a nanocarrier and an agonist for cGAS‐STING activation. These innovative DNA‐based multifunctional modules facilitate macrophage‐selective uptake and programmable STING activation.… read more here.
Keywords: immunotherapy; tumor immunotherapy; macrophage; tumor ... See more keywords
TREM2-Mediated Cholesterol Efflux in Macrophages Inhibits Anti-Tumor Immunity via Limitation of CD4+ T and NK Cells.
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DOI: 10.1002/advs.202506995
Abstract: Tumor-associated macrophages (TAMs) predominantly exert functions that facilitate tumor progression. Triggering receptor expressed on myeloid cell 2 (TREM2) is expressed in TAMs, playing a crucial role in mediating the immunosuppressive function of TAMs. The mechanisms by… read more here.
Keywords: cd4 cells; trem2; tumor; anti tumor ... See more keywords
Quercetin shows anti‐tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2388
Abstract: Hepatocellular carcinima is one of the most common tumors in clinic and also one of the leading causes of death from cancer worldwide. Quercetin shows significant effects on blocking the development of various cancers. read more here.
Keywords: effect hepatocellular; shows anti; anti tumor; quercetin ... See more keywords
Malt1 self‐cleavage is critical for regulatory T cell homeostasis and anti‐tumor immunity in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847597
Abstract: Mucosa‐associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF‐κB) signaling through both its adaptor and proteolytic function. Malt1 is also a target of its own protease… read more here.
Keywords: cleavage; anti tumor; malt1 self; self cleavage ... See more keywords