Low Dose Soft X‐Ray Remotely Triggered Lanthanide Nanovaccine for Deep Tissue CO Gas Release and Activation of Systemic Anti‐Tumor Immunoresponse
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DOI: 10.1002/advs.202004391
Abstract: Abstract Gas‐based therapy has emerged as a new green therapy strategy for anti‐tumor treatment. However, the therapeutic efficacy is still restricted by the deep tissue controlled release, poor lymphocytic infiltration, and inherent immunosuppressive tumor microenvironment… read more here.
Keywords: deep tissue; anti tumor; soft ray; tumor ... See more keywords
Quercetin shows anti‐tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway
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DOI: 10.1002/cam4.2388
Abstract: Hepatocellular carcinima is one of the most common tumors in clinic and also one of the leading causes of death from cancer worldwide. Quercetin shows significant effects on blocking the development of various cancers. read more here.
Keywords: effect hepatocellular; shows anti; anti tumor; quercetin ... See more keywords
Malt1 self‐cleavage is critical for regulatory T cell homeostasis and anti‐tumor immunity in mice
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DOI: 10.1002/eji.201847597
Abstract: Mucosa‐associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF‐κB) signaling through both its adaptor and proteolytic function. Malt1 is also a target of its own protease… read more here.
Keywords: cleavage; anti tumor; malt1 self; self cleavage ... See more keywords
Inhibition of Tumor-Associated Macrophages by trabectedin improves the anti-tumor adaptive immunity in response to anti-PD-1 therapy.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149379
Abstract: A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses and hence promote tumor immune evasion.… read more here.
Keywords: associated macrophages; tumor associated; anti tumor; adaptive immunity ... See more keywords
NAD+ salvage governs mitochondrial metabolism invigorating NK cell anti-tumor immunity.
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DOI: 10.1002/hep.32658
Abstract: BACKGROUND & AIMS Natural killer (NK) cells are key players in tumor immunosurveillance and metabolic adaption manipulates their fate and functional state. The nicotinamide adenine dinucleotide (NAD+ ) has emerged as a vital factor to… read more here.
Keywords: salvage; cell; metabolism; anti tumor ... See more keywords
IFN‐γ‐mediated inhibition of lung cancer correlates with PD‐L1 expression and is regulated by PI3K‐AKT signaling
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DOI: 10.1002/ijc.31357
Abstract: IFN‐γ plays a crucial role in anti‐tumor responses and also induces expression of PD‐L1, a well‐established inhibitor of anti‐tumor immune function. Understanding how molecular signaling regulates the function of IFN‐γ might improve its anti‐tumor efficacy.… read more here.
Keywords: ifn; pi3k akt; anti tumor; expression ... See more keywords
The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents.
Sign Up to like & getrecommendations! Published in 2021 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1717
Abstract: Immuno-oncotherapy has shown great promise for the cure of late-stage and metastatic cancer. Great efforts have tried to improve the overall response rate (ORR) and to reduce the immune-related adverse events (irAEs). Antigen presentation, T… read more here.
Keywords: immune responses; anti tumor; tumor immune; immuno oncotherapy ... See more keywords
Ganoderma immunomodulatory proteins: mushrooming functional FIPs.
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DOI: 10.1007/s00253-022-11839-9
Abstract: Fungal immunomodulatory protein (FIP) is a novel functional protein family with specific immunomodulatory activity identified from several macro-fungi. A variety of biological activities of FIPs have been reported, such as anti-allergy, anti-tumor, mitogenic activity, and… read more here.
Keywords: ganoderma immunomodulatory; immunomodulatory proteins; anti tumor; activity ... See more keywords
TIM-3 blockade combined with bispecific antibody MT110 enhances the anti-tumor effect of γδ T cells
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DOI: 10.1007/s00262-020-02638-0
Abstract: As ideal cells that can be used for adoptive cell therapy, γδ T cells are a group of homogeneous cells with high proliferative and tumor killing ability. However, γδ T cells are apt to apoptosis… read more here.
Keywords: antibody mt110; anti tumor; tim; bispecific antibody ... See more keywords
Anlotinib optimizes anti-tumor innate immunity to potentiate the therapeutic effect of PD-1 blockade in lung cancer
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DOI: 10.1007/s00262-020-02641-5
Abstract: Background Many anti-angiogenic agents have the potential to modulate the tumor microenvironment and improve immunotherapy. Anlotinib has demonstrated anti-tumor efficacy in non-small cell lung cancer (NSCLC) in third-line clinical trials. However, its roles in immune… read more here.
Keywords: anti tumor; anlotinib; lung cancer; tumor ... See more keywords
A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction
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DOI: 10.1007/s10637-019-00818-z
Abstract: The bromodomain and extra-terminal domain (BET) family of proteins, especially bromodomain-containing protein 4 (BRD4), has emerged as exciting anti-tumor targets due to their important roles in epigenetic regulation. Therefore, the discovery of BET inhibitors with… read more here.
Keywords: compound 171; apoptosis; bet; anti tumor ... See more keywords