Anti-tumour effect of neo-antigen-reactive T cells induced by RNA mutanome vaccine in mouse lung cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03735-y
Abstract: Mutation-specific T-cell response to epithelial cancers and T-cell-based immunotherapy has been successfully used to treat several human solid cancers. We aimed to investigate the anti-tumour effect of neo-antigen-reactive T(NRT) cells induced by RNA mutanome vaccine,… read more here.
Keywords: tumour effect; anti tumour; lung cancer; cancer ... See more keywords
Time for radioimmunotherapy: an overview to bring improvements in clinical practice
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-018-02027-1
Abstract: Harnessing the patient’s own immune system against an established cancer has proven to be a successful strategy. Within the last years, several antibodies blocking critical “checkpoints” that control the activation of T cells, the immune… read more here.
Keywords: bring improvements; time radioimmunotherapy; overview bring; anti tumour ... See more keywords
Using chemokine sorting to imrpove NK cell function in an anti-tumour model
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.341
Abstract: Background & Aim The immune system plays an important role in checking the development of tumours. While many inroads have been made into the role various immune cell types play within the context of cancer,… read more here.
Keywords: cancer; anti tumour; ccr2; chemokine ... See more keywords
Antiproliferative and Antitumour activity of saponins from Astragalus glycyphyllos on myeloid Graffi tumour.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113519
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Astragalus glycyphyllos L. has been extensively used in Bulgarian folk medicine as an antihypertensive, diuretic, anti-inflammatory, anti-tumour, in cases of cardiac insufficiency, renal inflammation, calculosis, etc. AIM OF THE STUDY: To evaluate the… read more here.
Keywords: graffi tumour; tumour cells; microscopy; astragalus glycyphyllos ... See more keywords
Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113598
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Dendrobium chrysotoxum Lindl is a cultivation of Dendrobium which belongs to the family of Orchidaceae. D. chrysotoxum Lindl is a traditional Chinese medicine with a wide range of clinical applications including tonic, astringent,… read more here.
Keywords: activity; expression; anti tumour; cell ... See more keywords
Investigation into the role of macrophages heterogeneity on solid tumour aggregations.
Sign Up to like & getrecommendations! Published in 2020 at "Mathematical biosciences"
DOI: 10.1016/j.mbs.2020.108325
Abstract: Macrophages are one of the most important immune cell populations that can be found inside solid tumours. For a long time, it was thought that these cells have an anti-tumour role, but relatively recent research… read more here.
Keywords: tumour cells; heterogeneity; investigation role; role ... See more keywords
Anti-tumour efficacy of etoposide alone and in combination with piroxicam against canine osteosarcoma in a xenograft model.
Sign Up to like & getrecommendations! Published in 2017 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.09.019
Abstract: Osteosarcoma (OSA) in dogs is locally invasive and highly malignant. Distant metastasis is the most common cause of death. To date, the survival rate in dogs with OSA remains poor. The cytotoxic effects of etoposide… read more here.
Keywords: combination; etoposide alone; alone combination; canine ... See more keywords
The complexity of neutrophils in health and disease: Focus on cancer
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in Immunology"
DOI: 10.1016/j.smim.2020.101409
Abstract: Neutrophils are essential soldiers of the immune response and their role have long been restricted to their activities in defence against microbial infections and during the acute phase of the inflammatory response. However, increasing number… read more here.
Keywords: focus; complexity neutrophils; biology; anti tumour ... See more keywords
Non-protein amino acid derivatives of 25-methoxylprotopanaxadiol/25-hydroxyprotopanaxadioland their anti-tumour activity evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2017.11.003
Abstract: HIGHLIGHTS25 novel protopanaxadiol analogs have been synthesized.Combine with non‐protein amino acids moiety exhibited anti‐canceractivities.Compounds 9 and 14 exhibited strong biological activity on cancer celllines. ABSTRACT As active components of ginseng, 25‐methoxylprotopanaxadiol and 25‐hydroxyprotopanaxadiol exhibited an… read more here.
Keywords: non protein; protein amino; activity; anti tumour ... See more keywords
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21409
Abstract: Although the main focus of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and adaptive arms of the immune system might produce superior tumour reduction and elimination. Tumour-associated macrophages often have… read more here.
Keywords: class; inhibition; hdac; anti tumour ... See more keywords
Gasdermin: a novel therapeutic target for tumour treatment by activating anti-tumour immunity
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0180-4
Abstract: A very recent study by Zhang et al. published in Nature demonstrates that gasdermin E (GSDME, also known as DFNA5) is a tumour suppressor by activating caspaseindependent pyroptosis to enhance anti-tumour immunity. In the meantime,… read more here.
Keywords: immunity; pyroptosis; gsdme; tumour suppression ... See more keywords