Extracellular production of recombinant N-glycosylated anti-VEGFR2 monobody in leaky Escherichia coli strain
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Letters"
DOI: 10.1007/s10529-019-02731-0
Abstract: To improve the production yield of N-glycosylated anti-VEGFR2 (vascular endothelial growth factor receptor 2) monobody (FN3VEGFR2-Gly) in lpp knockout Escherichia coli cells harboring Campylobacter jejuni N-glycosylation pathway. The leaky CLM37-Δlpp strain efficiently secreted FN3VEGFR2-Gly into… read more here.
Keywords: production; anti vegfr2; fn3vegfr2 gly; coli ... See more keywords
Anti-VEGFR2 nanobody expression in lettuce using an infectious Turnip mosaic virus vector
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Plant Biochemistry and Biotechnology"
DOI: 10.1007/s13562-017-0425-7
Abstract: Angiogenesis plays an important role in tumor growth and metastasis of cancer. Vascular endothelial growth factor is the key regulator in stimulating angiogenesis. The VEGF activity is mediated by binding to its cell-surface receptors, mainly… read more here.
Keywords: anti vegfr2; vegfr2 nanobody; mosaic virus; expression ... See more keywords
Novel human antibody against VEGFR2 shows therapeutic potential for leukemia and prostate cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer science"
DOI: 10.1111/cas.14208
Abstract: Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed in tumor-associated endothelial cells, where it modulates tumor-promoting angiogenesis, and it is also found on the surface of tumor cells. Currently, there are no antibody… read more here.
Keywords: anti vegfr2; prostate cancer; cancer; leukemia ... See more keywords
In vitro evaluation of anti-angiogenesis property of anti-VEGFR2 nanobody-conjugated H40-PEG carrier loaded with methotrexate
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.67038.14701
Abstract: Objective(s): In this study, Boltorn® H40-PEG-MTX-anti-VEGFR2 nanobody was fabricated in which nanobody was selected for blocking the receptor, H40 as a nanocarrier for delivery of methotrexate (MTX) to the tumor cells, and polyethylene glycol (PEG)… read more here.
Keywords: peg; anti vegfr2; vegfr2 nanobody; h40 peg ... See more keywords
“γδT Cell-IL17A-Neutrophil” Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.699478
Abstract: Angiogenesis is an essential physiological process and hallmark of cancer. Currently, antiangiogenic therapy, mostly targeting the vascular endothelial growth factor (VEGF)/VEGFR2 signaling axis, is commonly used in the clinic for solid tumors. However, antiangiogenic therapies… read more here.
Keywords: therapy; anti vegfr2; high dose; breast cancer ... See more keywords