Anti-virulence potential of 2-hydroxy-4-methoxybenzaldehyde against methicillin-resistant Staphylococcus aureus and its clinical isolates
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09941-6
Abstract: Burgeoning antibiotic resistance among bacterial pathogens necessitates the alternative treatment options to control the multidrug-resistant bacterial infections. Plant secondary metabolites, a significant source of structurally diverse compounds, posses several biological activities. The present study was… read more here.
Keywords: hydroxy methoxybenzaldehyde; methicillin resistant; anti virulence; virulence potential ... See more keywords
Impeding Virulence of Candida albicans by Candesartan and Domperidone.
Sign Up to like & getrecommendations! Published in 2021 at "Current microbiology"
DOI: 10.1007/s00284-021-02663-x
Abstract: Candida albicans is the most common human fungal pathogen that has developed extensive virulence factors which allows successful colonization and infection of the host. Anti-virulence agents can alleviate the pathogenesis of fungi and help the… read more here.
Keywords: domperidone candesartan; virulence; anti virulence; candida albicans ... See more keywords
On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome.
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c9md00146h
Abstract: The type III secretion system injectisome is a syringe-like multimembrane spanning nanomachine that is essential to the pathogenicity but not viability of many clinically relevant Gram-negative bacteria, such as enteropathogenic Escherichia coli, Salmonella enterica and… read more here.
Keywords: secretion; iii secretion; secretion system; anti virulence ... See more keywords
Small molecule based anti-virulence approaches against Candida albicans infections
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Microbiology"
DOI: 10.1080/1040841x.2021.2025337
Abstract: Abstract Fungi are considered “silent killers” due to the difficulty of, and delays in diagnosis of infections and lack of effective antifungals. This challenge is compounded by the fact that being eukaryotes, fungi share several… read more here.
Keywords: small molecule; anti virulence; virulence approaches; albicans infections ... See more keywords
The anti-virulence activity of the non-mevalonate pathway inhibitor FR900098 towards Burkholderia cenocepacia is maintained during experimental evolution.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001170
Abstract: Burkholderia cenocepacia infections are difficult to treat and there is an urgent need for alternative (combination) treatments. The use of anti-virulence therapies in combination with antibiotics is a possible strategy to increase the antimicrobial susceptibility… read more here.
Keywords: burkholderia cenocepacia; fr900098; activity; anti virulence ... See more keywords
Targeting the BspC-vimentin interaction to develop anti-virulence therapies during Group B streptococcal meningitis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010397
Abstract: Bacterial infections are a major cause of morbidity and mortality worldwide and the rise of antibiotic resistance necessitates development of alternative treatments. Pathogen adhesins that bind to host cells initiate disease pathogenesis and represent potential… read more here.
Keywords: interaction; anti virulence; meningitis; group ... See more keywords
Anti-virulence therapeutic strategies against bacterial infections: recent advances.
Sign Up to like & getrecommendations! Published in 2022 at "Germs"
DOI: 10.18683/germs.2022.1328
Abstract: The emergence and increasing prevalence of multidrug-resistant pathogens has become a major global healthcare problem. According to the World Health Organization if these trends continue, mortality from infection in 2050 will be higher than that… read more here.
Keywords: therapeutic strategies; anti virulence; virulence therapeutic; strategies bacterial ... See more keywords
Antifungal and anti-virulence activity of six essential oils against important Candida species - a preliminary study.
Sign Up to like & getrecommendations! Published in 2022 at "Future microbiology"
DOI: 10.2217/fmb-2021-0296
Abstract: Opportunistic infections with Candida species are becoming more problematic, considering their increasing virulence and resistance to antifungal drugs. AIM To assess the antifungal and anti-virulence activity of basil, cinnamon, clove, melaleuca, oregano and thyme essential… read more here.
Keywords: virulence activity; anti virulence; candida species; antifungal anti ... See more keywords
Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2019.00074
Abstract: Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this… read more here.
Keywords: toxin neutralization; therapeutic strategies; quorum sensing; anti virulence ... See more keywords
Peptidomimetics as Potential Anti-Virulence Drugs Against Resistant Bacterial Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.831037
Abstract: The uncontrollable spread of superbugs calls for new approaches in dealing with microbial-antibiotic resistance. Accordingly, the anti-virulence approach has arisen as an attractive unconventional strategy to face multidrug-resistant pathogens. As an emergent strategy, there is… read more here.
Keywords: drugs resistant; anti virulence; peptidomimetics potential; virulence ... See more keywords
Origanum vulgare ethanolic extracts as a promising source of compounds with antimicrobial, anti-biofilm, and anti-virulence activity against dental plaque bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.999839
Abstract: Dental caries and periodontal diseases remain a challenge for oral health, especially given the lack of effective and safe treatment options that are currently available. Against the backdrop of an ongoing antimicrobial resistance crisis, a… read more here.
Keywords: extract; anti virulence; antimicrobial anti; anti biofilm ... See more keywords