Anti-Wolbachia drugs for filariasis.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in parasitology"
DOI: 10.1016/j.pt.2021.06.004
Abstract: The mutualistic association between Wolbachia endosymbionts and their filarial nematode hosts has been exploited as a validated drug target delivering macrofilaricidal outcomes. Limitations of existing antibiotics to scale-up have driven the search for new drugs,… read more here.
Keywords: wolbachia drugs; anti wolbachia; drug; wolbachia ... See more keywords
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-07826-2
Abstract: Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia, for survival and fecundity, making Wolbachia a promising therapeutic target. Here we perform a high-throughput screen of AstraZeneca’s 1.3 million in-house compound library… read more here.
Keywords: industrial scale; anti wolbachia; throughput; lymphatic filariasis ... See more keywords
Development of a High-Throughput Cytometric Screen to Identify Anti-Wolbachia Compounds: The Power of Public–Private Partnership
Sign Up to like & getrecommendations! Published in 2019 at "Slas Discovery"
DOI: 10.1177/2472555219838341
Abstract: The Anti-Wolbachia (A·WOL) consortium at the Liverpool School of Tropical Medicine (LSTM) has partnered with the Global High-Throughput Screening (HTS) Centre at AstraZeneca to create the first anthelmintic HTS for neglected tropical diseases (NTDs). The… read more here.
Keywords: throughput; anti wolbachia; development high; high throughput ... See more keywords