Anti-tumoural [NHC(thiolato)]Au(I) complexes derived from HIF-1α inhibitor AC1-004 target the mitochondrial redox system and show antiangiogenic effects in vivo.
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DOI: 10.1002/cplu.202300167
Abstract: AC1-004 is a potent inhibitor of the hypoxia-inducible factor alpha (HIF-1α) pathway, essential for tumour growth, angiogenesis and metastasis. We modelled a series of gold(I) complexes on AC1-004, retaining its 5-carboalkoxybenzimidazole as an NHC ligand… read more here.
Keywords: antiangiogenic effects; gold complexes; inhibitor; ac1 004 ... See more keywords
Antitumor and antiangiogenic effects of Tonantzitlolone B, an uncommon diterpene from Stillingia loranthacea
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DOI: 10.1007/s00210-021-02185-0
Abstract: Natural products have played a pivotal role for the discovery of anticancer drugs. Tonantzitlolones are flexibilan-type diterpenes rare in nature; therefore, few reports have shown antiviral and cytotoxic activities. This study aimed to investigate the… read more here.
Keywords: tonantzitlolone uncommon; antiangiogenic effects; effects tonantzitlolone; antitumor antiangiogenic ... See more keywords
Antiproliferative and antiangiogenic effects of ammonium tetrathiomolybdate in a model of endometriosis.
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DOI: 10.1016/j.lfs.2021.120099
Abstract: AIMS Copper (Cu) is involved in the endometriosis progression. Herein, an experimental endometriosis model was used to evaluate whether its chelation with ammonium tetrathiomolybdate (TM) affects the proliferation and angiogenesis in endometriotic-like lesions and the… read more here.
Keywords: endometriosis; antiangiogenic effects; pathology; antiproliferative antiangiogenic ... See more keywords
Antiangiogenic effects of AA-PMe on HUVECs in vitro and zebrafish in vivo
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DOI: 10.2147/ott.s157747
Abstract: Angiogenesis plays a vital role in many physiological and pathological processes and several diseases are connected with its dysregulation. Asiatic acid (AA) has demonstrated anticancer properties and we suspect this might be attributable to an… read more here.
Keywords: angiogenesis; antiangiogenic effects; vivo; zebrafish embryos ... See more keywords