Polymyxin B-Polysaccharide Polyion Nanocomplex with Improved Biocompatibility and Unaffected Antibacterial Activity for Acute Lung Infection Management.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901542
Abstract: The decade-old antibiotic, polymyxin B (PMB), is regarded as the last line defense against gram-negative "superbug." However, the serious nephrotoxicity and neurotoxicity strongly obstruct further application of this highly effective antibiotic. Herein, a charge switchable… read more here.
Keywords: antibacterial activity; pmb; polyion nanocomplex; acute lung ... See more keywords
Ultrasound‐Enhanced Antibacterial Activity of Polymeric Nanoparticles for Eradicating Bacterial Biofilms
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201060
Abstract: Bacterial biofilms are a major healthcare concern resulting in refractory conditions such as chronic wounds, implant infections and failure, and multidrug‐resistant infections. Aggressive and invasive strategies are employed to cure biofilm infections but are prone… read more here.
Keywords: ultrasound enhanced; antibacterial activity; bacterial biofilms; polymeric nanoparticles ... See more keywords
Cinchonidinyl‐Based Acrylic and Methacrylic Homopolymers: Synthesis, Characterization, and Antibacterial Activity
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DOI: 10.1002/adv.21572
Abstract: The monomers (5-ethenyl-1-azabicyclo [2.2.2] octan-2-yl)-quinolin-4-ylmethyl acrylate (EAOQMA) and (5-ethenyl-1-azabicyclo [2.2.2] octan-2-yl)-quinolin-4-ylmethyl methacrylate (EAOQMMA) were synthesized by reacting (5-ethenyl-1-azabicyclo octan-2-yl)-quinolin-4-ylmethanol [cinchonidine] with acryloylchloride and methacryloyl chloride, respectively, in the presence of triethylamine. The homopolymers were synthesized… read more here.
Keywords: cinchonidinyl based; antibacterial activity; azabicyclo octan; octan quinolin ... See more keywords
Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing
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DOI: 10.1002/advs.202206585
Abstract: Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use of antibiotics for infected wound management. Hence, a versatile hydrogel dressing… read more here.
Keywords: antibacterial activity; wound healing; hydrogel; hydrogel dressing ... See more keywords
Synthesis, characterization, density functional theory studies and antibacterial activity of a new Schiff base dioxomolybdenum(VI) complex with tryptophan as epoxidation catalyst
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DOI: 10.1002/aoc.3782
Abstract: Appl Organometal Chem. 2017;e3782. https://doi.org/10.1002/aoc.3782 A cis‐dioxomolybdenum(VI) complex was prepared with MoO2(acac)2 and a Schiff base ligand (2‐((2‐hydroxybenzylidene)amino)‐3‐(1H‐indol‐3‐yl)propanoic acid) derived from salicylaldehyde and L‐tryptophan in ethanol and designated as [MoO2(Sal‐Tryp)(EtOH)]. It was characterized using several… read more here.
Keywords: density functional; antibacterial activity; functional theory; dioxomolybdenum complex ... See more keywords
Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film
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DOI: 10.1002/app.45794
Abstract: Propolis as a natural antibacterial agent was incorporated into the poly(vinyl alcohol) (PVA) in different forms of nanofiber, microfiber, and film. The successful fabrication of uniform nanofibers with 85–314 nm diameters and microfibers with 2.02… read more here.
Keywords: nanofibrous mat; mat film; antibacterial activity; film ... See more keywords
Semi‐synthesis, antibacterial activity, and molecular docking study of novel pleuromutilin derivatives bearing cinnamic acids moieties
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DOI: 10.1002/ardp.201800266
Abstract: To develop new antibiotics owning a special mechanism, we used the molecular assembly method to synthesize a series of novel pleuromutilin derivatives containing a cinnamic acid scaffold at the C‐14 side chain. We evaluated their… read more here.
Keywords: study; antibacterial activity; pleuromutilin derivatives; activity ... See more keywords
Synthesis, in vitro antibacterial activity against Mycobacterium tuberculosis, and reverse docking‐based target fishing of 1,4‐benzoxazin‐2‐one derivatives
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DOI: 10.1002/ardp.202000199
Abstract: Seventeen 1,4‐benzoxazin‐2‐ones bearing the enaminone moiety and three of their analogs were tested for the antibacterial activity against Mycobacterium tuberculosis (H37Rv). Minimal bactericidal concentrations (MBCs) were determined after 41 days of incubation by BACTEC. 1,4‐Benzoxazin‐2‐ones… read more here.
Keywords: antibacterial activity; tuberculosis; activity mycobacterium; reverse docking ... See more keywords
Conformational properties, membrane interaction, and antibacterial activity of the peptaibiotic chalciporin A: Multitechnique spectroscopic and biophysical investigations on the natural compound and labeled analogs
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DOI: 10.1002/bip.23083
Abstract: In this work, an extensive set of spectroscopic and biophysical techniques (including FT‐IR absorption, CD, 2D‐NMR, fluorescence, and CW/PELDOR EPR) was used to study the conformational preferences, membrane interaction, and bioactivity properties of the naturally… read more here.
Keywords: membrane interaction; antibacterial activity; labeled analogs; peptaibiotic chalciporin ... See more keywords
Synthesis and Antibacterial Activity of Sulfur‐linked Bis and Tris Heterocycles
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DOI: 10.1002/jhet.2878
Abstract: The bis and tris heterocycles-benzoxazolyl/benzothiazolyl/benzimidazolyl quinazolines linked by sulfur and/or nitrogen were prepared from 2,4-dichloroquinazoline and benzazolyl-2-thiol/benzazolyl-2-amine and studied their antibacterial activity. The nitro-substituted sulfur-linked bisbenzothiazolylquinazoline (12f), bisbenzimidazolylquinazoline (13f), and nitro-substituted sulfur and nitrogen-linked bisbenzothiazolylquinazoline… read more here.
Keywords: antibacterial activity; tris heterocycles; bis tris; sulfur linked ... See more keywords
Inhibitory mechanism of lactoferrin on antibacterial activity of oenothein B: isothermal titration calorimetry and computational docking simulation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.10271
Abstract: BACKGROUND Many foods contain proteins and polyphenols, but there is a poor understanding of the nature of the inhibitory effect of protein on the biologic activity of polyphenols. The inhibitory mechanism of the food protein… read more here.
Keywords: inhibitory mechanism; isothermal titration; antibacterial activity; lactoferrin antibacterial ... See more keywords