Recent updates of fluoroquinolones as antibacterial agents
Sign Up to like & getrecommendations! Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800141
Abstract: Fluoroquinolones remain one of the most important kind of antibacterial agents used nowadays. The emergence of more virulent and resistant strains of bacteria by the development of either mutated DNA‐binding proteins or efflux pump mechanism… read more here.
Keywords: antibacterial agents; recent updates; resistant strains; spectrum activity ... See more keywords
Exploration of (3‐benzyl‐5‐hydroxyphenyl)carbamates as new antibacterial agents against Gram‐positive bacteria
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DOI: 10.1002/ardp.201900294
Abstract: A series of (3‐benzyl‐5‐hydroxyphenyl)carbamates were evaluated as new antibacterial agents. Several compounds showed potent inhibitory activity against sensitive and drug‐resistant Gram‐positive bacteria. The compounds are ineffective against all tested Gram‐negative bacteria. The structure of the… read more here.
Keywords: new antibacterial; gram positive; hydroxyphenyl carbamates; positive bacteria ... See more keywords
Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents
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DOI: 10.1002/cmdc.202000002
Abstract: A series of novel quinoline and quinolinium iodide derivatives were designed and synthesized to discover potential anticancer and antibacterial agents. With regard to anticancer properties, in vitro cytotoxicities against three human cancer cell lines (A‐549, HeLa… read more here.
Keywords: quinolinium iodide; quinoline quinolinium; antibacterial agents; anticancer antibacterial ... See more keywords
Synthesis of arylfuran derivatives as potential antibacterial agents
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02711-y
Abstract: Bacterial infections represent a serious health care problem mainly due to the misuse and overuse of antibiotics, with consequent emergence of multidrug resistant bacterial strains. Then, because the urgent need to find novel and alternative… read more here.
Keywords: arylfuran derivatives; synthesis arylfuran; derivatives potential; antibacterial agents ... See more keywords
New 7-piperazinylquinolones containing (benzo[d]imidazol-2-yl)methyl moiety as potent antibacterial agents
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DOI: 10.1007/s11030-018-9834-3
Abstract: A series of 7-piperazinylquinolones containing a (benzo[d]imidazol-2-yl)methyl moiety were designed and synthesized as new antibacterial agents. The antibacterial activity of title compounds was evaluated against Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) and Gram-negative… read more here.
Keywords: antibacterial agents; containing benzo; benzo imidazol; imidazol methyl ... See more keywords
Carvacrol and its derivatives as antibacterial agents
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DOI: 10.1007/s11101-018-9569-x
Abstract: In recent years, essential oils constituents have attracted interest as alternative approach in the traditional medicine for their therapeutics properties. In this field, carvacrol, since it showed strong antimicrobial activity against a wide range of… read more here.
Keywords: medicine; antibacterial agents; carvacrol derivatives; chemistry ... See more keywords
Photolithographic-based stamp technique for improving the biocompatibility of antibacterial titanium implant by dynamic clearance of antibacterial agents
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.129756
Abstract: Abstract Antibacterial titanium implants used in orthopedic and oral tooth repair have been widely researched for reducing the occurrence of second replacement operation. Although possessing a good antibiosis effect, the traditional methods have poor biocompatibility… read more here.
Keywords: antibacterial agents; based stamp; biocompatibility; photolithographic based ... See more keywords
Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.070
Abstract: Methicillin and vancomycin resistant Staphylococcus aureus infections are an emerging global health concern leading to increasing morbidity and mortality. Continuous increase in drug resistance has underlined the need for discovery and development of new antibacterial… read more here.
Keywords: staphylococcus; staphylococcus aureus; triazole linked; antibacterial agents ... See more keywords
Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.
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DOI: 10.1016/j.ejmech.2019.04.063
Abstract: Antibiotic resistance remains a pressing medical challenge for which novel antibacterial agents are urgently needed. The phenylthiazole scaffold represents a promising platform to develop novel antibacterial agents for drug-resistant infections. However, enhancing the physicochemical profile… read more here.
Keywords: novel antibacterial; lipophilic efficient; antibacterial agents; undecaprenyl pyrophosphatase ... See more keywords
Synthesis and evaluation of new quinazolin-4(3H)-one derivatives as potent antibacterial agents against multidrug resistant Staphylococcus aureus and Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.067
Abstract: Staphylococcus aureus and Mycobacterium tuberculosis are major causative agents responsible for serious nosocomial and community-acquired infections impacting healthcare systems globally. Over several decades, these pathogens have developed resistance to multiple antibiotics significantly affecting morbidity and… read more here.
Keywords: antibacterial agents; one derivatives; quinazolin one; staphylococcus aureus ... See more keywords
Tyrosinase inhibitors as potential antibacterial agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111892
Abstract: Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses and… read more here.
Keywords: potential antibacterial; antibacterial agents; tyrosinase inhibitors; tyrosinase ... See more keywords