Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of Streptococcus pneumoniae Penicillin-Binding Protein 2x.
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DOI: 10.1021/acs.jmedchem.5c02273
Abstract: The allosteric site of penicillin-binding protein 2x (PBP2x), an essential enzyme of cell-wall biosynthesis of Streptococcus pneumoniae, was targeted in virtual screening of >2 M compounds. A benzimidazole-2-methanamine hit emerged, which exhibited a modest minimal-inhibitory… read more here.
Keywords: penicillin binding; antibacterial benzimidazole; benzimidazole methanamines; streptococcus pneumoniae ... See more keywords