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Synthesis, Cytostatic and Antibacterial Evaluations of Novel 1, 2, 3-Triazolyl-tagged Pyrimidine and Furo[2, 3-d]pyrimidine Derivatives

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Published in 2017 at "Croatica Chemica Acta"

DOI: 10.5562/cca3165

Abstract: C-5 alkynylated and N-1 alkylated pyrimidine derivatives were synthesized by N-alkylation reaction of 5-iodouracil in the presence of NaH, as a base, followed by Pd-catalyzed Sonogashira cross-coupling reaction of N-alkyl-5-iodouracil derivatives (1 and 2) with… read more here.

Keywords: furo pyrimidine; pyrimidine furo; pyrimidine derivatives; pyrimidine ... See more keywords