An Enzymatic Antibiotic Adjuvant Modulates the Infectious Microenvironment to Overcome Antimicrobial Resistance of Pathogens.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205471
Abstract: The emergence and evolution of antimicrobial resistance (AMR) pose a significant challenge to the current arsenal to fight infection. Antibiotic adjuvants represent an appealing tactic for tackling the AMR of pathogens, however, their practical applications… read more here.
Keywords: infectious microenvironment; infection; enzymatic antibiotic; antibiotic adjuvant ... See more keywords
Brominated Carbazole with Antibiotic Adjuvant Activity Displays Pleiotropic Effects in MRSA's Transcriptome.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00168
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a major threat to human health, as the US mortality rate outweighs those from HIV, tuberculosis, and viral hepatitis combined. In the wake of the COVID-19 pandemic, antibiotic-resistant bacterial infections… read more here.
Keywords: adjuvant activity; adjuvant; brominated carbazole; antibiotic adjuvant ... See more keywords
Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00482
Abstract: The difficulty in treating Gram-negative bacteria can largely be attributed to their highly impermeable outer membrane (OM), which serves as a barrier to many otherwise active antibiotics. This can be overcome with the use of… read more here.
Keywords: development; preclinical development; pentamidine; antibiotic adjuvant ... See more keywords
Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA
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DOI: 10.1021/acsmedchemlett.1c00680
Abstract: Antibiotic-resistant infections are a pressing global concern, causing millions of deaths each year. Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of nosocomial infections in healthcare settings and is increasingly responsible for community-acquired infections that… read more here.
Keywords: identification evaluation; brominated carbazoles; evaluation brominated; novel antibiotic ... See more keywords
The use of 4-Hexylresorcinol as antibiotic adjuvant
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DOI: 10.1371/journal.pone.0239147
Abstract: Ever decreasing efficiency of antibiotic treatment due to growing antibiotic resistance of pathogenic bacteria is a critical issue in clinical practice. The two generally accepted major approaches to this problem are the search for new… read more here.
Keywords: use hexylresorcinol; hexylresorcinol antibiotic; adjuvant; efficiency ... See more keywords
Menadione as Antibiotic Adjuvant Against P. aeruginosa: Mechanism of Action, Efficacy and Safety
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DOI: 10.3390/antibiotics14020163
Abstract: Background/Objectives: Antibiotic resistance in chronic lung infections caused by Pseudomonas aeruginosa requires alternative approaches to improve antibiotic efficacy. One promising approach is the use of adjuvant compounds that complement antibiotic therapy. This study explores the… read more here.
Keywords: lung; aeruginosa; efficacy; antibiotic adjuvant ... See more keywords