An Enzymatic Antibiotic Adjuvant Modulates the Infectious Microenvironment to Overcome Antimicrobial Resistance of Pathogens.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205471
Abstract: The emergence and evolution of antimicrobial resistance (AMR) pose a significant challenge to the current arsenal to fight infection. Antibiotic adjuvants represent an appealing tactic for tackling the AMR of pathogens, however, their practical applications… read more here.
Keywords: infectious microenvironment; infection; enzymatic antibiotic; antibiotic adjuvant ... See more keywords
Brominated Carbazole with Antibiotic Adjuvant Activity Displays Pleiotropic Effects in MRSA's Transcriptome.
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DOI: 10.1021/acschembio.2c00168
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a major threat to human health, as the US mortality rate outweighs those from HIV, tuberculosis, and viral hepatitis combined. In the wake of the COVID-19 pandemic, antibiotic-resistant bacterial infections… read more here.
Keywords: adjuvant activity; adjuvant; brominated carbazole; antibiotic adjuvant ... See more keywords
Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00482
Abstract: The difficulty in treating Gram-negative bacteria can largely be attributed to their highly impermeable outer membrane (OM), which serves as a barrier to many otherwise active antibiotics. This can be overcome with the use of… read more here.
Keywords: development; preclinical development; pentamidine; antibiotic adjuvant ... See more keywords
Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA
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DOI: 10.1021/acsmedchemlett.1c00680
Abstract: Antibiotic-resistant infections are a pressing global concern, causing millions of deaths each year. Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of nosocomial infections in healthcare settings and is increasingly responsible for community-acquired infections that… read more here.
Keywords: identification evaluation; brominated carbazoles; evaluation brominated; novel antibiotic ... See more keywords
The use of 4-Hexylresorcinol as antibiotic adjuvant
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DOI: 10.1371/journal.pone.0239147
Abstract: Ever decreasing efficiency of antibiotic treatment due to growing antibiotic resistance of pathogenic bacteria is a critical issue in clinical practice. The two generally accepted major approaches to this problem are the search for new… read more here.
Keywords: use hexylresorcinol; hexylresorcinol antibiotic; adjuvant; efficiency ... See more keywords