The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis††Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03530j
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DOI: 10.1039/c8sc03530j
Abstract: The condensation domain synthesising the last peptide bond in glycopeptide antibiotic biosynthesis has a preference for linear peptide substrates, with effective peptide formation linked to the rate of amino acid activation by the preceding adenylation… read more here.
Keywords: antibiotic biosynthesis; condensation domain; glycopeptide antibiotic;
SspH, a Novel HATPase Family Regulator, Controls Antibiotic Biosynthesis in Streptomyces
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DOI: 10.3390/antibiotics11050538
Abstract: Streptomyces can produce a wealth of pharmaceutically valuable antibiotics and other bioactive compounds. Production of most antibiotics is generally low due to the rigorously controlled regulatory networks, in which global/pleiotropic and cluster-situated regulatory proteins coordinate… read more here.
Keywords: biosynthesis; production; hatpase; ssph novel ... See more keywords