Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
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DOI: 10.1021/acs.jmedchem.3c02153
Abstract: Herein, we report the hit-to-lead identification of a drug-like pleuromutilin conjugate 16, based on a triaromatic hit reported in 2020. The lead arose as the clear candidate from a hit-optimization campaign in which Gram-positive antibacterial… read more here.
Keywords: hit lead; candidate hit; pleuromutilin; antibiotic candidate ... See more keywords
Altering the Solubility of the Antibiotic Candidate Nisin—A Computational Study
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DOI: 10.1021/acsomega.0c03594
Abstract: The growing bacterial resistance to available antibiotics makes it necessary to look for new drug candidates. An example is the lanthionine-containing nisin, which has a broad spectrum of antimicrobial activity. While nisin is widely utilized… read more here.
Keywords: antibiotic candidate; altering solubility; study; solubility ... See more keywords