Computational models, databases and tools for antibiotic combinations
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac309
Abstract: Antibiotic combination is a promising strategy to extend the lifetime of antibiotics and thereby combat antimicrobial resistance. However, screening for new antibiotic combinations is both time-consuming and labor-intensive. In recent years, an increasing number of… read more here.
Keywords: databases tools; computational models; models databases; antibiotic combinations ... See more keywords
Evaluation of synergistic activity of antibiotic combinations in extensive drug-resistant Acinetobacter species using checkerboard assay.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001639
Abstract: Introduction. Acinetobacter is one of the challenging drug-resistant organisms that can endanger patients' lives if not treated properly.Aim. This study was designed to investigate the activity of three synergistic antimicrobial combinations against extensive drug-resistant Acinetobacter… read more here.
Keywords: acinetobacter; sulbactam plus; antibiotic combinations; activity ... See more keywords
In vitro interaction of various antibiotic combinations recommended by Chinese consensus statement against carbapenems‐resistant Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2019 at "Letters in Applied Microbiology"
DOI: 10.1111/lam.13193
Abstract: Pseudomonas aeruginosa is related to nosocomial infections, and it tends to become resistant during or after antimicrobial treatment. The ability to develop carbapenems resistance makes it difficult to treat. P. aeruginosa infections are often associated… read more here.
Keywords: pseudomonas aeruginosa; consensus; antibiotic combinations; resistant aeruginosa ... See more keywords
Interaction Tolerance Detection Test for Understanding the Killing Efficacy of Directional Antibiotic Combinations
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DOI: 10.1128/mbio.00004-22
Abstract: The killing efficacy of antibiotic combinations is rarely measured in the clinical setting. However, in cases where the treatment is required to kill the infecting organism and not merely arrest its growth, the information on… read more here.
Keywords: killing efficacy; tolerance detection; antibiotic combinations; interaction tolerance ... See more keywords
ATP Bioluminescence Assay To Evaluate Antibiotic Combinations against Extensively Drug-Resistant (XDR) Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00651-22
Abstract: Combining antibiotics is one of the few strategies available to overcome infections caused by multidrug-resistant bacteria. Time-kill curves are usually performed to evaluate antibiotic combinations, but obtaining results is too laborious to be routinely performed… read more here.
Keywords: kill curves; antibiotic combinations; method; time kill ... See more keywords
Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Resistance and Infection Control"
DOI: 10.1186/s13756-017-0279-8
Abstract: Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically… read more here.
Keywords: burkholderia cepacia; combinations proposed; antibiotic combinations; cepacia complex ... See more keywords
A new pharmacodynamic approach to study antibiotic combinations against enterococci in vivo: Application to ampicillin plus ceftriaxone
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0243365
Abstract: The combination of ampicillin (AMP) and ceftriaxone (CRO) is considered synergistic against Enterococcus faecalis based on in vitro tests and the rabbit endocarditis model, however, in vitro assays are limited by the use of fixed… read more here.
Keywords: ampicillin; combination; antibiotic combinations; cro ... See more keywords
Prediction of Synergistic Antibiotic Combinations by Graph Learning
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.849006
Abstract: Antibiotic resistance is a major public health concern. Antibiotic combinations, offering better efficacy at lower doses, are a useful way to handle this problem. However, it is difficult for us to find effective antibiotic combinations… read more here.
Keywords: synergistic antibiotic; network; prediction synergistic; antibiotic combinations ... See more keywords
The Overlooked Issue of Outpatient Combination Antibiotic Prescribing in Low- and Middle-Income Countries: An Example from Syria
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DOI: 10.3390/antibiotics11010074
Abstract: This study aimed to determine and describe the prevalence of combination antibiotics dispensed in outpatients with health insurance in Syria. Data on all dispensed medicines between June 2018 and May 2019 for 81,314 adults were… read more here.
Keywords: issue outpatient; syria; combination; outpatient combination ... See more keywords
The Potential of Antibiotics and Nanomaterial Combinations as Therapeutic Strategies in the Management of Multidrug-Resistant Infections: A Review
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315038
Abstract: Antibiotic resistance has become a major public health concern around the world. This is exacerbated by the non-discovery of novel drugs, the development of resistance mechanisms in most of the clinical isolates of bacteria, as… read more here.
Keywords: nanomaterial combinations; antibiotics nanomaterial; antibiotic combinations; multidrug resistant ... See more keywords
Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11121420
Abstract: Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat. In recent times, increased rates of resistance have been reported not only to commonly used antibiotics, but also to the last-resort antibiotics, such as polymyxins.… read more here.
Keywords: negative pathogens; non antibiotic; gram negative; antibiotic combinations ... See more keywords