Understanding the Glycopeptide Antibiotic Crosslinking Cascade: In Vitro Approaches Reveal the Details of a Complex Biosynthesis Pathway
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DOI: 10.1002/cbic.202000309
Abstract: The glycopeptide antibiotics (GPAs) are a fascinating example of complex natural product biosynthesis, with the nonribosomal synthesis of the peptide core coupled to a cytochrome P450‐mediated cyclisation cascade that crosslinks aromatic side chains within this… read more here.
Keywords: crosslinking cascade; biosynthesis; antibiotic crosslinking; cascade ... See more keywords