NIAID's Comprehensive Support Mechanisms for Antibiotic Development.
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DOI: 10.1021/acsinfecdis.0c00099
Abstract: The National Institute of Allergy and Infectious Diseases (NIAID) recognizes the continuing threat of antimicrobial resistance and the need to develop new therapeutics and strategies to combat multidrug resistant organisms. NIAID leverages multiple mechanisms to… read more here.
Keywords: infectious diseases; support mechanisms; niaid comprehensive; comprehensive support ... See more keywords
Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.
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DOI: 10.1021/acsinfecdis.8b00275
Abstract: Bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. One such target is the tRNA-(N1G37) methyltransferase (TrmD), which is conserved and essential in… read more here.
Keywords: trmd; n1g37 methyltransferase; trna n1g37; antibiotic development ... See more keywords
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
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DOI: 10.1534/genetics.119.302851
Abstract: The imipridones ONC201 and ONC212 selectively kill cancer cells and have been ascribed multiple mechanisms-of-action. Genome-wide CRISPR knockout screens revealed that loss of the mitochondrial proteases CLPP and MIPEP confer strong resistance to both compounds...… read more here.
Keywords: protease; clpp; activate clpp; antibiotic development ... See more keywords
Derivation of a Precise and Consistent Timeline for Antibiotic Development
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DOI: 10.3390/antibiotics11091237
Abstract: Antibiotic resistance is a global health crisis. New classes of antibiotics that can treat drug-resistant infections are urgently needed. To communicate this message, researchers have used antibiotic development timelines, but these are often contradictory or… read more here.
Keywords: derivation precise; development; antibiotic development; timeline ... See more keywords