Antibiotic discovery: combining isolation chip (iChip) technology and co-culture technique
Sign Up to like & getrecommendations! Published in 2018 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-018-9193-0
Abstract: Antibiotics had been a useful tool for treating bacterial infections since their discovery, but with the passage of time, the evolution of resistance among microbes against antibiotics has rendered them useless. Many approaches are being… read more here.
Keywords: technique; antibiotic discovery; culture; ichip technology ... See more keywords
Antibiotics: past, present and future.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2019.10.008
Abstract: The first antibiotic, salvarsan, was deployed in 1910. In just over 100 years antibiotics have drastically changed modern medicine and extended the average human lifespan by 23 years. The discovery of penicillin in 1928 started… read more here.
Keywords: antibiotic discovery; antibiotics past; discovery; present future ... See more keywords
Fingerprint-Enhanced Graph Attention Network (FinGAT) Model for Antibiotic Discovery
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00045
Abstract: Artificial Intelligence (AI) techniques are of great potential to fundamentally change antibiotic discovery industries. Efficient and effective molecular featurization is key to all highly accurate learning models for antibiotic discovery. In this paper, we propose… read more here.
Keywords: fingerprint enhanced; enhanced graph; antibiotic discovery; model ... See more keywords
Antibiotic discovery in the artificial intelligence era
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14930
Abstract: As the global burden of antibiotic resistance continues to grow, creative approaches to antibiotic discovery are needed to accelerate the development of novel medicines. A rapidly progressing computational revolution—artificial intelligence—offers an optimistic path forward due… read more here.
Keywords: intelligence era; artificial intelligence; discovery artificial; antibiotic discovery ... See more keywords
High-Throughput Screening of Biodiversity for Antibiotic Discovery.
Sign Up to like & getrecommendations! Published in 2018 at "Acta Naturae"
DOI: 10.32607/20758251-2018-10-3-23-29
Abstract: The increasing number of infections caused by antibiotic-resistant strains of pathogens challenges modern technologies of drug discovery. Combinatorial chemistry approaches are based on chemical libraries. They enable the creation of high-affinity low-molecular-weight ligands of the… read more here.
Keywords: screening biodiversity; antibiotic discovery; high throughput; discovery ... See more keywords
Failing upwards: Genetics-based strategies to improve antibiotic discovery and efficacy in Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.932556
Abstract: Therapeutic advances in the 20th century significantly reduced tuberculosis (TB) mortality. Nonetheless, TB still poses a massive global health challenge with significant annual morbidity and mortality that has been amplified during the COVID-19 pandemic. Unlike… read more here.
Keywords: tuberculosis; improve antibiotic; genetic tools; antibiotic discovery ... See more keywords