Surfaces Containing Sharp Nanostructures Enhance Antibiotic Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c02182
Abstract: The ever-increasing rate of medical device implantations is met by a proportionately high burden of implant-associated infections. To mitigate this threat, much research has been directed toward the development of antibacterial surface modifications by various… read more here.
Keywords: nanostructures enhance; surfaces containing; enhance antibiotic; sharp nanostructures ... See more keywords
Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48506-8
Abstract: Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving selectively directing disease-causing proteins for degradation through proteolytic systems. Our ability to exploit targeted protein degradation (TPD) for antibiotic development remains nascent due to our limited… read more here.
Keywords: degradation; protein degradation; targeted protein; degradation mycobacteria ... See more keywords
N-Acetyl Cysteine and Vitamin C Modulate the Antibiotic Efficacy Against Escherichia coli Cells
Sign Up to like & getrecommendations! Published in 2025 at "Microbial Drug Resistance"
DOI: 10.1089/mdr.2024.0135
Abstract: Supplements with their own beneficial effect on hosts are consumed by us. N-acetyl cysteine (NAC) and Vitamin C (Vit C) are antioxidants and supplements, consumed for their beneficial properties. The present investigation evaluates the effect… read more here.
Keywords: escherichia coli; acetyl cysteine; log increase; efficacy escherichia ... See more keywords
Toward Enhanced Antibiotic Efficacy: Exploring the Synergistic Potential of Marine-Derived Lectins Against Human Pathogenic Bacteria.
Sign Up to like & getrecommendations! Published in 2024 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765202420240072
Abstract: This study aimed to assess the combined antibacterial effect of lectins and antibiotics on S. aureus ATCC 25923, multidrug-resistant E. coli ATCC 11303 and S. aureus ATCC 700698. Using the checkerboard assay, we evaluated the… read more here.
Keywords: enhanced antibiotic; exploring synergistic; efficacy; efficacy exploring ... See more keywords
Novel Antibiotic Testing Approaches Reveal Reduced Antibiotic Efficacy Against Shiga Toxin-Producing Escherichia coli O157:H7 Under Simulated Microgravity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.03214
Abstract: As a foodborne and environmental pathogen, Shiga toxin-producing Escherichia coli O157:H7 could pose a health threat to immunocompromised astronauts during a space mission. In this study, novel approaches, including real-time testing and direct evaluation of… read more here.
Keywords: antibiotic efficacy; escherichia coli; coli o157; toxin producing ... See more keywords
Cadmium’s silent sabotage: unveiling its impact on antibiotic efficacy
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1658173
Abstract: Despite advancements in non-antibiotic therapies, antibiotics continue to be the cornerstone of bacterial infection management. However, the overuse of antibiotics has led to an increase in clinical failures, a situation worsened by the phenomenon of… read more here.
Keywords: silent sabotage; cadmium; impact; antibiotic efficacy ... See more keywords
The Complex Intracellular Lifecycle of Staphylococcus aureus Contributes to Reduced Antibiotic Efficacy and Persistent Bacteremia
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25126486
Abstract: Staphylococcus aureus bacteremia continues to be associated with significant morbidity and mortality, despite improvements in diagnostics and management. Persistent infections pose a major challenge to clinicians and have been consistently shown to increase the risk… read more here.
Keywords: antibiotic efficacy; staphylococcus aureus; bacteremia; persistent bacteremia ... See more keywords
Sodium Malonate Inhibits the AcrAB-TolC Multidrug Efflux Pump of Escherichia coli and Increases Antibiotic Efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11121409
Abstract: There is an urgent need to find novel treatments for combating multidrug-resistant bacteria. Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this problem. Therefore, using efflux pump inhibitors (EPIs) is… read more here.
Keywords: sodium malonate; efficacy; antibiotic efficacy; multidrug efflux ... See more keywords