Emulating Target Trials to Avoid Immortal Time Bias – An Application to Antibiotic Initiation and Preterm Delivery
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DOI: 10.1097/ede.0000000000001601
Abstract: Background: Randomized trials in pregnancy are extremely challenging, and observational studies are often the only option to evaluate medication safety during pregnancy. However, such studies are often susceptible to immortal time bias if treatment initiation… read more here.
Keywords: target trials; time; immortal time; time bias ... See more keywords
Reductions in hospitalisations and emergency department visits with early antibiotic initiation in nontuberculous mycobacterial lung disease
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DOI: 10.1183/23120541.00963-2023
Abstract: Background While antibiotics are recommended for treatment of nontuberculous mycobacterial lung disease (NTMLD), the impact of early antibiotic initiation on healthcare resource utilisation is unclear. This study compared healthcare resource utilisation with early versus delayed… read more here.
Keywords: antibiotic initiation; initiation; nontuberculous mycobacterial; delayed antibiotic ... See more keywords
Timing of antibiotic initiation in sepsis and neutropenic fever
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DOI: 10.3389/fmed.2025.1597047
Abstract: Introduction Sepsis, as a life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a leading cause of mortality worldwide. The condition requires rapid treatment, and The Surviving Sepsis Campaign from 2021 recommend… read more here.
Keywords: antibiotic initiation; mortality; increased mortality; timing antibiotic ... See more keywords