Decreased Growth and Antibiotic Production in Streptomyces coelicolor A3(2) by Deletion of a Highly Conserved DeoR Family Regulator, SCO1463
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-019-0084-8
Abstract: Streptomyces spp. have been isolated from different environmental niches and are known to exhibit diversity in secondary metabolism. They have complex regulation system to control secondary metabolism, however it is difficult to prioritize the importance… read more here.
Keywords: antibiotic production; streptomyces coelicolor; production; growth antibiotic ... See more keywords
Use of elicitors to enhance or activate the antibiotic production in streptomyces.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in biotechnology"
DOI: 10.1080/07388551.2021.1987856
Abstract: Streptomyces is the largest and most significant genus of Actinobacteria, comprising 961 species. These Gram-positive bacteria produce many versatile and important bioactive compounds; of these, antibiotics, specifically the enhancement or activation of their production, have… read more here.
Keywords: enhance activate; antibiotic production; production; elicitors enhance ... See more keywords
Redox-sensitive transcriptional regulator SoxR directly controls antibiotic production, development and thiol-oxidative stress response in Streptomyces avermitilis.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial biotechnology"
DOI: 10.1111/1751-7915.13813
Abstract: The redox-sensitive transcriptional regulator SoxR is conserved in bacteria. Its role in mediating protective response to various oxidative stresses in Escherichia coli and related enteric bacteria has been well established. However, functions and regulatory mechanisms… read more here.
Keywords: thiol oxidative; antibiotic production; sav; soxr ... See more keywords
Identification of glucose kinase‐dependent and ‐independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics
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DOI: 10.1111/mmi.13714
Abstract: Summary Members of the soil-dwelling prokaryotic genus Streptomyces are indispensable for the recycling of complex polysaccharides, and produce a wide range of natural products. Nutrient availability is a major determinant for the switch to development… read more here.
Keywords: antibiotic production; streptomyces coelicolor; development antibiotic; metabolism ... See more keywords
BldD, a master developmental repressor, activates antibiotic production in two Streptomyces species
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DOI: 10.1111/mmi.14405
Abstract: BldD generally functions as a repressor controlling morphological development of Streptomyces. In this work, evidences that BldD also activates antibiotic production are provided. In Streptomyces roseosporus (which produces daptomycin widely used for treatment of human… read more here.
Keywords: bldd; antibiotic production; production; daptomycin production ... See more keywords
Multifactorial genetic control and magnesium levels govern the production of a Streptomyces antibiotic with unusual cell density dependence
Sign Up to like & getrecommendations! Published in 2024 at "mSystems"
DOI: 10.1128/msystems.01368-23
Abstract: ABSTRACT Streptomyces bacteria are renowned both for their antibiotic production capabilities and for their cryptic metabolic potential. Their metabolic repertoire is subject to stringent genetic control, with many of the associated biosynthetic gene clusters being… read more here.
Keywords: cell density; control; density; antibiotic production ... See more keywords
Functional connexion of bacterioferritin in antibiotic production and morphological differentiation in Streptomyces coelicolor
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DOI: 10.1186/s12934-024-02510-1
Abstract: Several two-component systems of Streptomyces coelicolor, a model organism used for studying antibiotic production in Streptomyces, affect the expression of the bfr (SCO2113) gene that encodes a bacterioferritin, a protein involved in iron storage. In… read more here.
Keywords: differentiation; iron; bfr; streptomyces coelicolor ... See more keywords
Regulation of Antibiotic Production by Signaling Molecules in Streptomyces
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.02927
Abstract: The genus Streptomyces is a unique subgroup of actinomycetes bacteria that are well-known as prolific producers of antibiotics and many other bioactive secondary metabolites. Various environmental and physiological signals affect the onset and level of… read more here.
Keywords: production signaling; regulation antibiotic; antibiotic production; signaling molecules ... See more keywords
The Streptomyces coelicolor Small ORF trpM Stimulates Growth and Morphological Development and Exerts Opposite Effects on Actinorhodin and Calcium-Dependent Antibiotic Production
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DOI: 10.3389/fmicb.2020.00224
Abstract: In actinomycetes, antibiotic production is often associated with a morpho-physiological differentiation program that is regulated by complex molecular and metabolic networks. Many aspects of these regulatory circuits have been already elucidated and many others still… read more here.
Keywords: trpm stimulates; antibiotic production; streptomyces coelicolor; trpm ... See more keywords
The Phosin PptA Plays a Negative Role in the Regulation of Antibiotic Production in Streptomyces lividans
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DOI: 10.3390/antibiotics10030325
Abstract: In Streptomyces, antibiotic biosynthesis is triggered in phosphate limitation that is usually correlated with energetic stress. Polyphosphates constitute an important reservoir of phosphate and energy and a better understanding of their role in the regulation… read more here.
Keywords: regulation antibiotic; antibiotic production; ppta; role regulation ... See more keywords
Advocacy for Responsible Antibiotic Production and Use
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11070980
Abstract: Antibiotic-resistant bacteria have become one of humankind’s major challenges, as testified by the UN’s Call to Action on Antimicrobial Resistance in 2021. Our knowledge of the underlying processes of antibiotic resistance is steadily improving. Beyond… read more here.
Keywords: antibiotic production; advocacy responsible; production; responsible antibiotic ... See more keywords