Sample-efficient identification of high-dimensional antibiotic synergy with a normalized diagonal sampling design
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DOI: 10.1371/journal.pcbi.1010311
Abstract: Antibiotic resistance is an important public health problem. One potential solution is the development of synergistic antibiotic combinations, in which the combination is more effective than the component drugs. However, experimental progress in this direction… read more here.
Keywords: efficient identification; sample efficient; identification high; design ... See more keywords
An Optimized Checkerboard Method for Phage-Antibiotic Synergy Detection
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DOI: 10.3390/v14071542
Abstract: Phage-antibiotic synergy is a promising therapeutic strategy, but there is no reliable method for synergism estimation. Although the time-kill curve assay is a gold standard, the method is not appropriate for fast and extensive screening… read more here.
Keywords: checkerboard method; phage antibiotic; antibiotic synergy; synergy ... See more keywords