Antibodies that neutralize cellular uptake of elosulfase alfa are not associated with reduced efficacy or pharmacodynamic effect in individuals with Morquio A syndrome.
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DOI: 10.1016/j.jim.2016.10.006
Abstract: Many enzyme replacement therapies (ERTs) for lysosomal storage disorders use the cell-surface cation-independent mannose-6 phosphate receptor (CI-M6PR) to deliver ERTs to the lysosome. However, neutralizing antibodies (NAb) may interfere with this process. We previously reported… read more here.
Keywords: antibodies neutralize; individuals morquio; efficacy; neutralize cellular ... See more keywords
Characterization of human monoclonal antibodies that neutralize multiple poliovirus serotypes.
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DOI: 10.1016/j.vaccine.2017.03.038
Abstract: Following the eradication of wild poliovirus (PV), achieving and maintaining a polio-free status will require eliminating potentially pathogenic PV strains derived from the oral attenuated vaccine. For this purpose, a combination of non-cross-resistant drugs, such… read more here.
Keywords: antibodies neutralize; monoclonal antibodies; human monoclonal; cross neutralization ... See more keywords