Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits
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DOI: 10.1016/j.isci.2021.102454
Abstract: Summary Nearly all clinical isolates of Salmonella Typhi, the cause of typhoid fever, are antibiotic resistant. All S. Typhi isolates secrete an A2B5 exotoxin called typhoid toxin to benefit the pathogen during infection. Here, we… read more here.
Keywords: targeting glycan; glycan receptor; toxin; antibodies targeting ... See more keywords
Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
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DOI: 10.1038/s41467-018-07008-0
Abstract: Zika virus is a mosquito-borne flavivirus closely related to dengue virus that can cause severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Specific treatments and vaccines for Zika virus are… read more here.
Keywords: protection; disease; human antibodies; antibodies targeting ... See more keywords
Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03294-z
Abstract: Human cytomegalovirus (HCMV) is a β-herpesvirus that increases morbidity and mortality in immunocompromised individuals including transplant recipients and newborns. New anti-HCMV therapies are an urgent medical need for diverse patient populations. HCMV infection of a… read more here.
Keywords: broadly neutralizing; targeting cytomegalovirus; development broadly; neutralizing antibodies ... See more keywords
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern
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DOI: 10.1126/scitranslmed.abj5413
Abstract: Description Bispecific antibodies targeting multiple regions of the SARS-CoV-2 spike protein comparably neutralize variants of concern and wild-type virus. A bispecific approach to COVID-19 Monoclonal antibodies (mAbs) have become an essential component of coronavirus disease… read more here.
Keywords: variants concern; spike protein; bispecific antibodies; antibodies targeting ... See more keywords
Antibodies Targeting the Cell Wall Induce Protection against Virulent Mycobacterium bovis Infection
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DOI: 10.1128/spectrum.03431-22
Abstract: M. bovis is the causative agent of animal tuberculosis (TB) and human TB. Research on M. bovis is of great public health significance. ABSTRACT Accumulating evidence indicates that antibodies can protect against some intracellular pathogens.… read more here.
Keywords: bovis; cell; protection; bovis infection ... See more keywords
Abstract 3274: Novel cell-based bioassays for mono- and multi-specific antibodies targeting PD-1/PD-L1 for combination immunotherapy
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DOI: 10.1158/1538-7445.am2023-3274
Abstract: Programmed cell death protein 1 (PD-1) is an immune checkpoint (IC) receptor that negatively regulates T cell function. Blocking the interaction of PD-1 with its ligands PD-L1 or PD-L2 unleashes the immune system and enhances… read more here.
Keywords: cell; novel cell; combination; receptor ... See more keywords
Safety profile of monoclonal antibodies targeting the calcitonin gene-related peptide system in pregnancy: Updated analysis in VigiBase®
Sign Up to like & getrecommendations! Published in 2023 at "Cephalalgia"
DOI: 10.1177/03331024231158083
Abstract: Background Safety data on the use of migraine preventive monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) system in pregnancy are limited. Methods Updated pharmacovigilance assessment of the safety reports related to pregnancy associated with… read more here.
Keywords: system; safety; pregnancy; monoclonal antibodies ... See more keywords
Antibodies targeting enzyme inhibition as potential tools for research and drug development
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DOI: 10.1515/bmc-2021-0021
Abstract: Abstract Antibodies have transformed biomedical research and are now being used for different experimental applications. Generally, the interaction of enzymes with their specific antibodies can lead to a reduction in their enzymatic activity. The effect… read more here.
Keywords: inhibition; targeting enzyme; research; inhibition potential ... See more keywords
Human antibodies targeting ENPP1 as candidate therapeutics for cancers
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DOI: 10.3389/fimmu.2023.1070492
Abstract: Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein expressed in many tissues. High expression levels of ENPP1 have been observed in many cancer types such as lung cancer, ovarian cancer, and breast cancer.… read more here.
Keywords: targeting enpp1; enpp1 candidate; candidate therapeutics; human antibodies ... See more keywords
Finding the Right Heavy Chains for Immunostimulatory Antibodies
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DOI: 10.3390/ijms231810367
Abstract: For twelve years, the oncology field has been revolutionized by antibodies targeting immune checkpoints. They must be considered as a heterogenous family of immunostimulatory antibodies displaying very different mechanisms of action, not only depending on… read more here.
Keywords: antibodies targeting; immunostimulatory antibodies; right heavy; heavy chains ... See more keywords
Collection of Monoclonal Antibodies Targeting SARS-CoV-2 Proteins
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DOI: 10.3390/v14020443
Abstract: In early 2020, the COVID-19 pandemic sparked a global crisis that continues to pose a serious threat to human health and the economy. Further advancement in research is necessary and requires the availability of quality… read more here.
Keywords: collection monoclonal; sars cov; targeting sars; monoclonal antibodies ... See more keywords