Demographic and Clinical Factors Associated With Anti–SARS-CoV-2 Antibody Levels After 2 BNT162b2 mRNA Vaccine Doses
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.12996
Abstract: Key Points Question What factors are associated with serum levels of anti–SARS-CoV-2 antibodies after COVID-19 vaccination in healthy young and middle-aged persons at 6 months? Findings In this cohort study of 50 individuals, anti–SARS-CoV-2–specific antibody… read more here.
Keywords: vaccination; factors associated; antibody; anti sars ... See more keywords
Comparison of Maternal and Neonatal Antibody Levels After COVID-19 Vaccination vs SARS-CoV-2 Infection
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DOI: 10.1001/jamanetworkopen.2022.40993
Abstract: This cohort study examines the response to COVID-19 vaccination, exposure to SARS-CoV-2 infection, timing of infection or vaccination, and placental antibody transfers among pregnant persons and their newborns. read more here.
Keywords: vaccination; infection; covid vaccination; antibody ... See more keywords
Humanized 3F8 Anti-GD2 Monoclonal Antibody Dosing With Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Resistant Neuroblastoma: A Phase 1 Clinical Trial
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DOI: 10.1001/jamaoncol.2018.4005
Abstract: Importance Chimeric and murine anti-GD2 antibodies are active against neuroblastoma, but the development of neutralizing antibodies can compromise efficacy. To decrease immunogenicity, hu3F8, a humanized anti-GD2 antibody, was constructed. Objective To find the maximum-tolerated dose… read more here.
Keywords: trial; anti gd2; antibody; cycle ... See more keywords
Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma: A Phase 2 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.5999
Abstract: Importance Among patients with high-risk relapsed metastatic neuroblastoma, oral β-glucan adjuvant during GD2/GD3 ganglioside vaccine boost has stimulated IgG antibody response, which was associated with improved survival; however, the effectiveness of oral β-glucan during the… read more here.
Keywords: patients high; high risk; oral glucan; vaccine ... See more keywords
Development of an anti‐BAG3 humanized antibody for treatment of pancreatic cancer
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DOI: 10.1002/1878-0261.12492
Abstract: We have previously shown that secreted BAG3 is a potential target for the treatment of pancreatic ductal adenocarcinoma and that pancreatic tumor growth and metastatic dissemination can be reduced by treatment with an anti‐BAG3 murine… read more here.
Keywords: anti bag3; treatment; antibody; pancreatic cancer ... See more keywords
Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody
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DOI: 10.1002/2211-5463.13084
Abstract: Cluster of differentiation 47 (CD47) is a widely expressed self‐protection transmembrane protein that functions as a critical negative regulator to induce macrophage‐mediated phagocytosis. Overexpression of CD47 enables cancer cells to escape immune surveillance and destruction… read more here.
Keywords: cd47 antibody; cd47; antibody; anti cd47 ... See more keywords
Haemophilus influenzae Protein D antibody suppression in a multi‐component vaccine formulation
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DOI: 10.1002/2211-5463.13498
Abstract: Nontypeable Haemophilus influenzae (NTHi) has emerged as a dominant mucosal pathogen causing acute otitis media (AOM) in children, acute sinusitis in children and adults, and acute exacerbations of chronic bronchitis in adults. Consequently, there is an… read more here.
Keywords: vaccine formulation; haemophilus influenzae; vaccine; antibody ... See more keywords
Clinical profile of autoimmune nodopathy with anti-neurofascin 186 antibody.
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DOI: 10.1002/acn3.51775
Abstract: OBJECTIVE Nodal/paranodal autoantibodies identified a group of peripheral neuropathies independent from chronic inflammatory demyelinating polyneuropathy (CIDP). However, nodopathy with antibody against neurofascin 186 (NF186) was rarely reported. We presented a cohort of patients with anti-NF186… read more here.
Keywords: clinical profile; anti; anti nf186; nodopathy anti ... See more keywords
Ultrasensitive NIR‐SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation
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DOI: 10.1002/adhm.201700870
Abstract: Immunotargeting ability of antibodies may show significant difference between in vitro and in vivo. To select antibody leads with high affinity and specificity, it is necessary to perform in vivo validation of antibody candidates following… read more here.
Keywords: validation; vivo; nir serrs; antibody ... See more keywords
Biomaterials-Based Delivery of Therapeutic Antibodies for Cancer Therapy.
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DOI: 10.1002/adhm.202002139
Abstract: Considerable breakthroughs in the treatment of malignant tumors using antibody drugs, especially immunomodulating monoclonal antibodies (mAbs), have been made in the past decade. Despite technological advancements in antibody design and manufacture, multiple challenges face antibody-mediated… read more here.
Keywords: delivery; antibody; biomaterials based; cancer ... See more keywords
Crystalline Antibody-Laden Alginate Particles: A Platform for Enabling High Concentration Subcutaneous Delivery of Antibodies.
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DOI: 10.1002/adhm.202202370
Abstract: Subcutaneous administration is a desired route for monoclonal antibodies (mAbs). However, formulating mAbs for small injection volumes at high concentrations with suitable stability and injectability is a significant challenge. Here we present a platform technology… read more here.
Keywords: alginate particles; crystalline antibody; antibody laden; high concentration ... See more keywords