A synthetic human antibody antagonizes IL-18Rβ signaling through an allosteric mechanism.
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DOI: 10.1016/j.jmb.2020.01.012
Abstract: The interleukin-18 subfamily belongs to the interleukin-1 family and plays important roles in modulating innate and adaptive immune responses. Dysregulation of IL-18 has been implicated in or correlated with numerous diseases including inflammatory diseases, autoimmune… read more here.
Keywords: antibody antagonizes; allosteric mechanism; synthetic human; human antibody ... See more keywords