Standardised neutralising antibody assays are needed for evaluating COVID-19 vaccines
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103677
Abstract: In this article of EBioMedicine, Viviana Simon and colleagues show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine remains effective against emerging SARS-CoV-2 variants of concern/interest in neutralisation and binding activities of serological… read more here.
Keywords: vaccine; neutralising antibody; covid; standardised neutralising ... See more keywords
Generation and characterization of luciferase-secreting, single-round infectious DENV-2 reporter for functional antibody assays.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2021.114119
Abstract: Flavivirus reporters provide a robust tool for viral pathogenesis studies, anti- viral drug screening, disease diagnosis and functional antibody assays. In this study, we generated a luciferase-secreting, single-round reporter virus by replacing the capsid coding… read more here.
Keywords: reporter; reporter virus; luciferase; functional antibody ... See more keywords
Side by side comparison of three fully automated SARS-CoV-2 antibody assays with a focus on specificity
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Chemistry"
DOI: 10.1093/clinchem/hvaa198
Abstract: Abstract Background In the context of the COVID-19 pandemic, numerous new serological test systems for the detection of anti-SARS-CoV-2 antibodies rapidly have become available. However, the clinical performance of many of these is still insufficiently… read more here.
Keywords: antibody assays; cov antibody; sars cov; roche diasorin ... See more keywords
Comparison of the Results of Five SARS-CoV-2 Antibody Assays before and after the First and Second ChAdOx1 nCoV-19 Vaccinations among Health Care Workers: a Prospective Multicenter Study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01788-21
Abstract: Reliable results for serological positivity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody after the second dose of AstraZeneca (AZ) vaccination are important to estimate the real efficacy of vaccination. We evaluated positivity rates… read more here.
Keywords: first second; antibody assays; cov antibody; vaccination ... See more keywords
Retrospective Evaluation of Various Serological Assays and Multiple Parameters for Optimal Diagnosis of Lyme Neuroborreliosis in a Routine Clinical Setting
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00061-22
Abstract: The diagnosis of LNB is established by clinical symptoms, pleocytosis, and proof of intrathecal synthesis of Borrelia-specific antibodies. Laboratory diagnosis of LNB is challenging, and validated diagnostic algorithms are lacking. ABSTRACT Laboratory diagnosis of Lyme… read more here.
Keywords: diagnosis; serology; lnb diagnosis; antibody assays ... See more keywords
Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron Variant
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02129-22
Abstract: This study demonstrates that the antigenic changes of the SARS-CoV-2 Omicron variant affect test results from commercial Spike- and RBD-specific antibody assays, significantly diminishing their sensitivities and diagnostic abilities to assess neutralizing antibodies. ABSTRACT The… read more here.
Keywords: variant; sars cov; cov omicron; antibody ... See more keywords
Comparison of six antibody assays and two combination assays for COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Virology Journal"
DOI: 10.1186/s12985-022-01752-y
Abstract: Introduction In this work, six SARS-CoV-2-specific antibody assays were evaluated, namely, two pan-immunoglobulin (pan-Ig) assays [Roche Elecsys Anti-SARS-CoV-2 (named "Elecsys" in this study) and the PerkinElmer SuperFlex™ Anti-SARS-CoV-2 Ab Assay (SuperFlex_Ab)], two IgM assays [SuperFlex™… read more here.
Keywords: igg; sars cov; combination; antibody assays ... See more keywords
Performance Comparison of Five SARS-CoV-2 Antibody Assays for Seroprevalence Studies
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DOI: 10.3343/alm.2022.42.1.71
Abstract: Background Seroprevalence studies of coronavirus disease 2019 (COVID-19) cases, including asymptomatic and past infections, are important to estimate the scale of the disease outbreak and to establish quarantine measures. We evaluated the clinical performance of… read more here.
Keywords: seroprevalence studies; cov antibody; sars cov; antibody assays ... See more keywords
Antiphospholipid Antibody Assays in 2021: Looking for a Predictive Value in Addition to a Diagnostic One
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.726820
Abstract: Antiphospholipid antibodies (aPL) are mandatory for the diagnosis but are also a risk factor for the antiphospholipid syndrome (APS) clinical manifestations. Lupus anticoagulant (LA), anticardiolipin (aCL), and anti-beta2 glycoprotein I (β2GPI) assays are the formal… read more here.
Keywords: addition; diagnostic prognostic; value; assays 2021 ... See more keywords