Neutralising antibody escape of SARS‐CoV‐2 spike protein: Risk assessment for antibody‐based Covid‐19 therapeutics and vaccines
Sign Up to like & getrecommendations! Published in 2021 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2231
Abstract: Summary The Spike protein is the target of both antibody‐based therapeutics (convalescent plasma, polyclonal serum, monoclonal antibodies) and vaccines. Mutations in Spike could affect efficacy of those treatments. Hence, monitoring of mutations is necessary to… read more here.
Keywords: antibody based; escape; antibody; spike protein ... See more keywords
Current progress in innovative engineered antibodies
Sign Up to like & getrecommendations! Published in 2017 at "Protein & Cell"
DOI: 10.1007/s13238-017-0457-8
Abstract: ABSTRACTAs of May 1, 2017, 74 antibody-based molecules have been approved by a regulatory authority in a major market. Additionally, there are 70 and 575 antibody-based molecules in phase III and phase I/II clinical trials,… read more here.
Keywords: antibody based; progress; delivery; antibody ... See more keywords
Antibody-Based Therapies for Cutaneous T-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Clinical Dermatology"
DOI: 10.1007/s40257-018-0402-5
Abstract: Cutaneous T-cell lymphomas (CTCLs) are a group of non-Hodgkin’s lymphomas that present in the skin. In early-stage disease, the course is generally chronic and indolent; however, in advanced stages of disease, therapies rarely provide long-lasting… read more here.
Keywords: cutaneous cell; antibody based; based therapies; antibody ... See more keywords
Eph receptors as cancer targets for antibody-based therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2020.04.007
Abstract: Receptor tyrosine kinases (RTKs) are integral membrane sensors that govern cell differentiation, proliferation and mobility, and enable rapid communication between cells and their environment. Of the 20 RTK subfamilies currently known, Eph receptors are the… read more here.
Keywords: antibody based; eph receptors; receptors cancer; cancer targets ... See more keywords
Monoclonal antibody-based cancer therapies
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Chemical Engineering"
DOI: 10.1016/j.cjche.2020.11.009
Abstract: Abstract Targeted therapy has been widely demonstrated as an effective strategy to treat cancers, the leading cause of death in the world. This minireview summarizes the technical platforms and methodologies utilized to develop and engineer… read more here.
Keywords: antibody based; based cancer; antibody; cancer therapies ... See more keywords
Discovery of targeted expression data for novel antibody-based and chimeric antigen receptor-based therapeutics in soft tissue sarcomas using RNA-sequencing: clinical implications.
Sign Up to like & getrecommendations! Published in 2021 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2021.100794
Abstract: Recent failure of phase 3 trials and paucity of druggable oncogenic drivers hamper developmental therapeutics in sarcomas. Antibody-based therapeutics, like antibody-drug conjugates (ADCs) and chimeric antigen receptor (CAR)-based therapeutics, have emerged as promising strategies for… read more here.
Keywords: antibody based; based therapeutics; expression; antigen receptor ... See more keywords
M71 HIGH-THROUGHPUT ANTIBODY-BASED PROFILING OF SERUM IN SCHIZOPHRENIA AND BIPOLAR DISORDER PATIENTS: AN INTEGRATIVE GENOMICS-PROTEOMICS PILOT STUDY
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.378
Abstract: Background The identification of biological markers in the peripheral blood for the prediction of the individual clinical outcome has an enormous potential in the frame of personalized medicine. Previous studies have already tried to create… read more here.
Keywords: protein; antibody based; study; serum ... See more keywords
Detection of kanamycin and gentamicin residues in animal-derived food using IgY antibody based ic-ELISA and FPIA.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2017.01.058
Abstract: Our aim in this study is to show that IgY antibody based immunoassays could be used to detect antibiotic residues in animal-derived food. Briefly, full antigens of gentamicin (Gent) and kanamycin (Kana) were used to… read more here.
Keywords: antibody based; detection; igy antibody; animal derived ... See more keywords
Development of formaldehyde dehydrogenase‐coupled assay and antibody‐based assays for ALKBH5 activity evaluation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.09.018
Abstract: &NA; N6‐methyladenosine (m6A) is the most prevalent internal modification of eukaryotic messenger RNA (mRNA). Until now, two RNA demethylases have been identified, including FTO (fat mass and obesity‐associated protein) and ALKBH5 (&agr;‐ketoglutarate‐dependent dioxygenase alkB homologue… read more here.
Keywords: antibody based; assays alkbh5; dehydrogenase coupled; formaldehyde dehydrogenase ... See more keywords
Use of a monoclonal antibody-based assay for the early detection of an invasive bivalve in plankton samples.
Sign Up to like & getrecommendations! Published in 2018 at "Marine pollution bulletin"
DOI: 10.1016/j.marpolbul.2018.05.004
Abstract: The invasive mussel Xenostrobus securis was recorded for the first time in the Galician Rias Baixas (NW Spain) in 2007, within an area characterized by intense commercial culture of Mytilus galloprovincialis. The main aims of… read more here.
Keywords: antibody based; antibody; use monoclonal; based assay ... See more keywords
A brief history of antibody-based therapy
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2019.104504
Abstract: Active and passive immunization have been used to treat human disease for hundreds of years and improvements in technology and knowledge is only increasing the number of therapeutic applications. The current and future use of… read more here.
Keywords: antibody based; brief history; history antibody; based therapy ... See more keywords