Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions
Sign Up to like & getrecommendations! Published in 2019 at "Current Allergy and Asthma Reports"
DOI: 10.1007/s11882-019-0848-4
Abstract: Purpose of ReviewAllergen-antibody complexes are extremely valuable in describing the detailed molecular features of epitopes. This review summarizes insights gained from recently published co-structures and what obstacles impede the acquisition of further data.Recent FindingsStructural epitope… read more here.
Keywords: analysis recent; antibody; antibody complexes; structural analysis ... See more keywords
Switchable assembly and function of antibody complexes in vivo using a small molecule
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117402119
Abstract: Significance Reported here, we describe a molecular protein technology to enable switchable assembly of functional antibody complexes. This approach, which we call ligand-induced transient engagement (LITE), allows for control of an antibody’s intended function in… read more here.
Keywords: small molecule; function; antibody complexes; switchable assembly ... See more keywords
Complement activation by AAV-neutralizing antibody complexes.
Sign Up to like & getrecommendations! Published in 2023 at "Human gene therapy"
DOI: 10.1089/hum.2023.018
Abstract: Treatment of monogenetic disorders using adeno-associated viral vectors (AAV) is an area of intense interest. AAV is a human pathogen and pre-existing capsid antibodies are prevalent in the population posing a challenge to safety and… read more here.
Keywords: aav neutralizing; complement activation; antibody complexes; neutralizing antibody ... See more keywords