Protein-Templated Reactions Using DNA-Antibody Conjugates.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200971
Abstract: DNA-templated chemical reactions have found wide applications in drug discovery, programmed multistep synthesis, nucleic acid detection, and targeted drug delivery. The control of these reactions has, however, been limited to nucleic acid hybridization as a… read more here.
Keywords: dna; antibody conjugates; dna antibody; templated reactions ... See more keywords
Degrader-antibody conjugates.
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DOI: 10.1039/d2cs00141a
Abstract: Degrader-antibody conjugates (DACs) are novel entities that combine a proteolysis targeting chimera (PROTAC) payload with a monoclonal antibody via some type of chemical linker. This review provides a current summary of the DAC field. Many… read more here.
Keywords: degrader antibody; antibody conjugates; antibody;
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc02198f
Abstract: Antibody–drug conjugates (ADCs) are valuable therapeutic entities which leverage the specificity of antibodies to selectively deliver cytotoxins to antigen-expressing targets such as cancer cells. However, current methods for their construction still suffer from a number… read more here.
Keywords: conjugates modular; antibody conjugates; generation antibody; antibody ... See more keywords
Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer
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DOI: 10.1080/2162402x.2017.1331195
Abstract: ABSTRACT Despite the high interest and concern due to an increasing incidence and death rate, patients who develop muscle invasive bladder cancer (MIBC) have few options available. However, the past decade has produced many candidate… read more here.
Keywords: antibody conjugates; invasive bladder; bladder cancer; antibody ... See more keywords
Novel Human Bispecific Aptamer–Antibody Conjugates for Efficient Cancer Cell Killing
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DOI: 10.3390/cancers11091268
Abstract: Monoclonal antibodies have been approved by the Food and Drug Administration for the treatment of various human cancers. More recently, oligonucleotide aptamers have risen increasing attention for cancer therapy thanks to their low size (efficient… read more here.
Keywords: aptamer antibody; antibody; cancer cell; cancer ... See more keywords