SUBCUTANEOUS IMMUNOGLOBULINS IN CHRONIC LYMPHOCYTIC LEUKAEMIA WITH SECONDARY ANTIBODY DEFICIENCY. A MONOCENTRIC EXPERIENCE DURING COVID-19 PANDEMICS.
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DOI: 10.1002/hon.2966
Abstract: Secondary antibody deficiency (SAD) is a frequent manifestation of chronic lymphocytic leukaemia (CLL) that increases the risk of infections. However, no formal guideline are available regarding the eligibility for prophylaxis or the delivery method, dosage,… read more here.
Keywords: cll; secondary antibody; covid; antibody deficiency ... See more keywords
Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group
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DOI: 10.1007/s10875-018-0577-9
Abstract: Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial… read more here.
Keywords: bronchial pathology; bronchiectasis; group; pathology ... See more keywords
COVID-19 and X-linked agammaglobulinemia (XLA) - insights from a monogenic antibody deficiency.
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DOI: 10.1097/aci.0000000000000792
Abstract: PURPOSE OF REVIEW The clinical outcomes from COVID-19 in monogenic causes of predominant antibody deficiency have pivotal implications for our understanding of the antiviral contribution of humoral immunity. This review summarizes the lessons learned from… read more here.
Keywords: agammaglobulinemia xla; covid; antibody deficiency; linked agammaglobulinemia ... See more keywords
Expanding the clinical features of autoinflammation and phospholipase Cγ2‐associated antibody deficiency and immune dysregulation by description of a novel patient
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DOI: 10.1111/jdv.15918
Abstract: Autoinflammation and phospholipase Cγ2‐associated antibody deficiency and immune dysregulation (APLAID) is an exceedingly rare monogenic autoinflammatory disease. To date, only five cases have been reported with four distinct pathogenic mutations. read more here.
Keywords: deficiency immune; associated antibody; antibody deficiency; immune dysregulation ... See more keywords
Fatal fungal endocarditis in a patient with primary antibody deficiency
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DOI: 10.1136/jclinpath-2016-204232
Abstract: Pathogens have well recognised patterns of infections but these rules are often violated in immunocompromised hosts leading to infections by atypical organisms at unexpected sites. While many of the immunodeficiency syndromes could be pinpointed to… read more here.
Keywords: antibody deficiency; fungal endocarditis; deficiency; patient ... See more keywords
Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency
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DOI: 10.1136/thoraxjnl-2020-215585
Abstract: Bronchiectasis is a well-recognised complication of primary antibody deficiency (PAD) syndromes. Previous data suggest that mortality in common variable immune deficiency (CVID) is not associated with isolated bronchiectasis. A retrospective analysis of patients with CVID… read more here.
Keywords: bronchiectasis; primary antibody; mortality; antibody deficiency ... See more keywords
Specific Antibody Deficiency: Controversies in Diagnosis and Management
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DOI: 10.3389/fimmu.2017.00586
Abstract: Specific antibody deficiency (SAD) is a primary immunodeficiency disease characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination.… read more here.
Keywords: response; patients sad; specific antibody; antibody ... See more keywords
Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy
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DOI: 10.3389/fimmu.2019.02484
Abstract: Primary immunodeficiencies are heritable disorders of immune function. CD19 is a B cell co-receptor important for B cell development, and CD19 deficiency is a known genetic risk factor for a rare form of primary immunodeficiency… read more here.
Keywords: antibody deficiency; physiology; deficiency; cd19 mice ... See more keywords
A Retrospective Study on the Efficacy of Subcutaneous Immunoglobulin as Compared to Intravenous Formulation in Patients with Chronic Lymphocytic Leukemia and Secondary Antibody Deficiency
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DOI: 10.3390/curroncol30010022
Abstract: Secondary antibody deficiency (SAD) is a common complication in chronic lymphocytic leukemia (CLL) which favors the development of life-threatening infections. Subcutaneous immunoglobulins (IG) (SCIG) have been proven to be as effective as intravenous immunoglobulin (IVIG)… read more here.
Keywords: chronic lymphocytic; antibody deficiency; study; secondary antibody ... See more keywords
Correlation between Clinical and Immunological Variables and Humoral Response to SARS-CoV-2 Vaccination in Adult Patients with Antibody Deficiency Disorders
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DOI: 10.3390/pathogens11111364
Abstract: Background. Prophylactic vaccination has proven to be the most effective strategy to fight the COVID-19 pandemic. Methods. This was a prospective observational cohort study involving 30 predominantly antibody deficiency disorders (ADD)-afflicted adult patients on immunoglobulin… read more here.
Keywords: antibody deficiency; vaccination; humoral response; deficiency disorders ... See more keywords