Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8: a direct comparison with radio-iodinated Exendin-4
Sign Up to like & getrecommendations! Published in 2017 at "Acta Diabetologica"
DOI: 10.1007/s00592-017-1059-x
Abstract: AbstractAim The zinc transporter 8 (ZnT8) has been suggested as a suitable target for non-invasive visualization of the functional pancreatic beta cell mass, due to both its pancreatic beta cell restricted expression and tight involvement… read more here.
Keywords: comparison radio; direct comparison; ab31; znt8 ... See more keywords
99mTc(CO)3+ labeled domain I/II-specific anti-EGFR (scFv)2 antibody fragment for imaging EGFR expression.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.014
Abstract: Bifunctional chelators (BFCs) are covalently linked to biologically active targeting molecules and radiolabeled with radiometals. Technetium-99 m (99mTc) is the most widely used isotope in nuclear medicine because of its excellent physical properties. The objective of… read more here.
Keywords: antibody; scfv; anti egfr; dlo6 scfv ... See more keywords
Unravelling enhancement of antibody fragment stability - Role of format structure and cysteine modification.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2018.10.012
Abstract: Antibody-based diagnostics and therapeutics have huge commercial value. However, applications of antibodies are often limited by instability, particularly for recombinant antibody formats. This paper describes the conversion of a single-chain variable fragment (scFv) antibody to… read more here.
Keywords: format; unravelling enhancement; enhancement antibody; antibody ... See more keywords
Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein–Protein Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03665
Abstract: Protein–protein interactions (PPIs) form complex networks to drive cellular signaling and cellular functions. Precise modulation of a target PPI helps explain the role of the PPI in cellular events and possesses therapeutic potential. For example,… read more here.
Keywords: protein protein; p97; ppi; antibody fragment ... See more keywords
A Novel Cell-Penetrating Antibody Fragment Inhibits the DNA Repair Protein RAD51
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47600-y
Abstract: DNA damaging chemotherapies are successful in cancer therapy, however, the damage can be reversed by DNA repair mechanisms that may be up-regulated in cancer cells. We hypothesized that inhibiting RAD51, a protein involved in homologous… read more here.
Keywords: antibody fragment; cell penetrating; dna repair; repair ... See more keywords
Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc04531a
Abstract: Disulfide bridging, also known as disulfide stapling, is a powerful strategy for the construction of site-selective protein bioconjugates. Here we describe the first examples of a new class of such reagents, containing a ‘stable-labile’ design.… read more here.
Keywords: reactivity disulfide; bioconjugation; bridging reagents; disulfide bridging ... See more keywords
Recombinant production of the antibody fragment D1.3 scFv with different Bacillus strains
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Cell Factories"
DOI: 10.1186/s12934-017-0625-9
Abstract: BackgroundDifferent strains of the genus Bacillus are versatile candidates for the industrial production and secretion of heterologous proteins. They can be cultivated quite easily, show high growth rates and are usually non-pathogenic and free of… read more here.
Keywords: scfv different; production; antibody; antibody fragment ... See more keywords
Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188191
Abstract: Aβ-Immunotherapy has long been studied in the treatment of Alzheimer’s disease (AD), but not how other molecules involved in the disease can affect antibody performance. We previously designed an antibody fragment, scFv-h3D6, and showed that… read more here.
Keywords: mimetic peptides; apoj; scfv h3d6; h3d6 ... See more keywords
Microbial platform technology for recombinant antibody fragment production: A review
Sign Up to like & getrecommendations! Published in 2017 at "Critical Reviews in Microbiology"
DOI: 10.3109/1040841x.2016.1150959
Abstract: Abstract Recombinant antibody fragments are being used for the last few years as an important therapeutic protein to cure various critical and life threatening human diseases. Several expression platforms now days employed for the production… read more here.
Keywords: recombinant antibody; production; antibody; expression ... See more keywords
Minibody-Based and scFv-Based Antibody Fragment-Drug Conjugates Selectively Eliminate GD2-Positive Tumor Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021239
Abstract: Ganglioside GD2 is a well-established target expressed on multiple solid tumors, many of which are characterized by low treatment efficiency. Antibody-drug conjugates (ADCs) have demonstrated marked success in a number of solid tumors, and GD2-directed… read more here.
Keywords: tumor; fragment drug; drug conjugates; drug ... See more keywords