Laser‐Fabricated 2D Molybdenum Disulfide Electronic Sensor Arrays for Rapid, Low‐Cost, Ultrasensitive Detection of Influenza A and SARS‐Cov‐2
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202102209
Abstract: Multiplex electronic antigen sensors for detection of SARS‐Cov‐2 spike glycoproteins and hemagglutinin from influenza A are fabricated using scalable processes for straightforward transition to economical mass‐production. The sensors utilize the sensitivity and surface chemistry of… read more here.
Keywords: antibody fragments; influenza; detection; laser fabricated ... See more keywords
Selection of Antibody Fragments Against Structured DNA by Phage Display.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8648-4_11
Abstract: In addition to the canonical B-form structure, DNA can adopt alternative conformations including Z DNA, triplex DNA, as well as G4 and i-Motif quadruplex structures. Such structures have been shown to form in cells in… read more here.
Keywords: phage display; structured dna; fragments structured; antibody fragments ... See more keywords
Production of Stabilized Antibody Fragments in the E. coli Bacterial Cytoplasm and in Transiently Transfected Mammalian Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8958-4_23
Abstract: Monoclonal antibodies (mAbs) are currently the fastest growing class of therapeutic proteins. Parallel to full-length IgG format the development of recombinant technologies provided the production of smaller recombinant antibody variants. The single-chain variable fragment (scFv)… read more here.
Keywords: coli bacterial; production; antibody; bacterial cytoplasm ... See more keywords
Influence of Molecular size on the clearance of antibody fragments
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DOI: 10.1007/s11095-017-2219-y
Abstract: PurposeTo establish a continuous relationship between the size of various antibody fragments and their systemic clearance (CL) in mice.MethodsTwo different orthogonal approaches have been used to establish the relationship. First approach uses CL values estimated… read more here.
Keywords: protein size; size; clearance; relationship ... See more keywords
Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.12.009
Abstract: ABSTRACT Pulmonary administration of anti‐cytokine antibodies offers a targeted therapy in asthma. However, the rapid elimination of proteins from the lungs limits the efficacy of inhaled medications. PEGylation has been shown to increase the residence… read more here.
Keywords: residence time; delivery; antibody fragments;
Site-Specific Modification of Single-Chain Antibody Fragments for Bioconjugation and Vascular Immunotargeting.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00592
Abstract: The conjugation of antibodies to drugs and drug carriers improves delivery to target tissues. Widespread implementation and effective translation of this pharmacologic strategy awaits the development of affinity ligands capable of a defined degree of… read more here.
Keywords: chain antibody; site specific; chemistry; modification ... See more keywords
Short FcRn-Binding Peptides Enable Salvage and Transcytosis of scFv Antibody Fragments.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00862
Abstract: Therapeutic antibodies have become one of the most widely used classes of biotherapeutics due to their unique antigen specificity and their ability to be engineered against diverse disease targets. There is significant interest in utilizing… read more here.
Keywords: size; fcrn; short fcrn; fcrn binding ... See more keywords
Ion Channel Targeting with Antibodies and Antibody Fragments for Cancer Diagnosis
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DOI: 10.3390/antib8020033
Abstract: The antibody era has greatly impacted cancer management in recent decades. Indeed, antibodies are currently applied for both cancer diagnosis and therapy. For example, monoclonal antibodies are the main constituents of several in vitro diagnostics,… read more here.
Keywords: cancer; antibodies antibody; cancer diagnosis; antibody fragments ... See more keywords
Smaller size packs a stronger punch - Recent advances in small antibody fragments targeting tumour-associated carbohydrate antigens
Sign Up to like & getrecommendations! Published in 2023 at "Theranostics"
DOI: 10.7150/thno.80901
Abstract: Attached to proteins, lipids, or forming long, complex chains, glycans represent the most versatile post-translational modification in nature and surround all human cells. Unique glycan structures are monitored by the immune system and differentiate self… read more here.
Keywords: antibody fragments; carbohydrate antigens; associated carbohydrate; tumour associated ... See more keywords
Generation and diversification of recombinant monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.72093
Abstract: Antibodies are indispensable tools used for a large number of applications in both foundational and translational bioscience research; however, there are drawbacks to using traditional antibodies generated in animals. These include a lack of standardization… read more here.
Keywords: recombinant monoclonal; monoclonal antibodies; antibody fragments; generation diversification ... See more keywords