Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation
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DOI: 10.1002/bit.28066
Abstract: Glycosylation can be a critical quality attribute in biologic manufacturing. In particular, it has implications on the half‐life, immunogenicity, and pharmacokinetics of therapeutic monoclonal antibodies (mAbs), and must be closely monitored throughout drug development and… read more here.
Keywords: therapeutic antibody; antibody glycosylation; glycosylation; downstream ... See more keywords
Study on antibody Fc-glycosylation for optimal effector functions.
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DOI: 10.1039/d3cc00672g
Abstract: A comprehensive structure-activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2,6 sialylated biantennary complex type glycan was identified as the optimal Fc-glycan with significant… read more here.
Keywords: glycosylation optimal; study antibody; effector functions; antibody glycosylation ... See more keywords
Monitoring of immunoglobulin N- and O-glycosylation in health and disease
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DOI: 10.1093/glycob/cwz048
Abstract: Abstract Protein N- and O-glycosylation are well known co- and post-translational modifications of immunoglobulins. Antibody glycosylation on the Fab and Fc portion is known to influence antigen binding and effector functions, respectively. To study associations… read more here.
Keywords: antibody glycosylation; analysis; monitoring immunoglobulin; glycosylation ... See more keywords
Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity
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DOI: 10.1111/imm.13481
Abstract: In this study we show that glycosylation is relevant for immune recognition of therapeutic antibodies, and that defined glycan structures can modulate immunogenicity. Concerns regarding immunogenicity arise from the high heterogeneity in glycosylation that is… read more here.
Keywords: recognition; antigen recognition; immunogenicity; antibody glycosylation ... See more keywords